Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | DRD4 | P21917 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9558544 | 1.00 | MTNR1A (0.60) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| SCHEMBL9558556 | 0.90 | DRD2 (0.68) | MTNR1AMTNR1BDRD2DRD4DRD3 | |
| SCHEMBL8890686 | 0.86 | MTNR1A (0.66) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| SCHEMBL8893102 | 0.82 | MTNR1A (0.62) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| Hydrochloric Acid SCHEMBL7935647 | 0.81 | MTNR1A (0.60) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| SCHEMBL4518779 | 0.81 | DRD2 (0.80) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| SCHEMBL7543876 | 0.81 | DRD2 (0.80) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| SCHEMBL8891575 | 0.80 | MTNR1A (0.60) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| Hydrochloric Acid SCHEMBL7543024 | 0.80 | DRD2 (0.78) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| SCHEMBL9355070 | 0.80 | MTNR1A (0.66) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0452390-B1 | HALO SUBSTITUTED AMINOTETRALINS | UPJOHN CO (US) | 1994-10-26 | — | — | EP | disclosed |
| US-5225596-A | Halo substituted aminotetralins | THE UPJOHN COMPANY (US) | 1993-07-06 | — | — | US | disclosed |
| EP-0452390-A1 | HALO SUBSTITUTED AMINOTETRALINS. | UPJOHN CO (US) | 1991-10-23 | — | — | EP | disclosed |
| WO-1990007490-A1 | HALO SUBSTITUTED AMINOTETRALINS | THE UPJOHN COMPANY (US) | 1990-07-12 | — | — | WO | disclosed |