Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CACNA1G | O43497 | 6/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9356279 | 1.00 | MC4R (0.56) | MC4RHPGDUSP2ALDH1A1CACNA1G | |
| SCHEMBL9356274 | 1.00 | MC4R (0.56) | MC4RHPGDUSP2ALDH1A1CACNA1G | |
| SCHEMBL6685347 | 0.83 | MC4R (0.58) | MC4RHPGDUSP2ALDH1A1CACNA1G | |
| SCHEMBL172539 | 0.83 | MC4R (0.58) | MC4RHPGDUSP2ALDH1A1CACNA1G | |
| SCHEMBL30254694 | 0.81 | MC4R (0.55) | MC4RHPGDUSP2ALDH1A1CACNA1G | |
| Hydrochloric Acid SCHEMBL15142852 | 0.79 | MC4R (0.54) | MC4RHPGDUSP2ALDH1A1CACNA1G | |
| SCHEMBL19234012 | 0.77 | MC4R (0.57) | MC4RHPGDUSP2ALDH1A1CACNA1G | |
| SCHEMBL15149552 | 0.76 | HPGD (0.56) | MC4RHPGDUSP2ALDH1A1CACNA1G | |
| SCHEMBL19476409 | 0.76 | HPGD (0.56) | MC4RHPGDUSP2ALDH1A1CACNA1G | |
| SCHEMBL30239976 | 0.75 | MC4R (0.74) | MC4RHPGDUSP2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299513-B1 | Azetidine derivatives, compositions and their use | FIDIA GEORGETOWN INST (US) | 1994-10-05 | — | — | EP | disclosed |
| US-4990504-A | Modulate excitatory amino acid receptor system | FIDIA-GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) | 1991-02-05 | — | — | US | disclosed |
| US-4946839-A | ALZHEIMER'S DISEASE | FIDIA-GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) | 1990-08-07 | — | — | US | disclosed |
| EP-0299513-A1 | Azetidine derivatives, compositions and their use | FIDIA-GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) | 1989-01-18 | — | — | EP | disclosed |