Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.57 |
| ▸ | DPP4 | P27487 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ANPEP | P15144 | 2/20 | 0.46 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MASP2 | O00187 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19234280 | 0.84 | CFD (0.46) | MC4RDPP4DPP8DPP9DPP7 | |
| SCHEMBL1162854 | 0.84 | MC4R (0.59) | MC4RDPP4HPGDUSP2ALDH1A1 | |
| SCHEMBL18576456 | 0.83 | CTSC (0.59) | MC4RDPP4HPGDUSP2ALDH1A1 | |
| SCHEMBL18556183 | 0.83 | CTSC (0.59) | MC4RDPP4HPGDUSP2ALDH1A1 | |
| SCHEMBL7067405 | 0.83 | CTSC (0.59) | MC4RDPP4HPGDUSP2ALDH1A1 | |
| SCHEMBL25111799 | 0.83 | CTSC (0.59) | MC4RDPP4HPGDUSP2ALDH1A1 | |
| SCHEMBL19233889 | 0.82 | P2RX7 (0.48) | MC4RALDH1A1DPP8DPP9DPP7 | |
| Hydrochloric Acid SCHEMBL18546507 | 0.82 | CTSC (0.58) | MC4RDPP4HPGDUSP2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL18554365 | 0.82 | CTSC (0.58) | MC4RDPP4HPGDUSP2ALDH1A1 | |
| SCHEMBL19234311 | 0.81 | GID4 (0.44) | HPGDDPP8DPP9DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661433-B1 | INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) | NOVARTIS AG (CH) | 2017-08-16 | — | — | EP | disclosed |