Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | FKBP1A | P62942 | 8/20 | 0.54 |
| ▸ | FABP7 | O15540 | 1/20 | 0.47 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9352186 | 1.00 | ALDH1A1 (0.54) | ALDH1A1FKBP1AFABP7FABP5TDP1 | |
| SCHEMBL9352202 | 0.96 | FKBP1A (0.51) | ALDH1A1FKBP1AFABP7FABP5TDP1 | |
| SCHEMBL9352606 | 0.93 | FKBP1A (0.49) | ALDH1A1FKBP1AFABP7FABP5TDP1 | |
| SCHEMBL9352588 | 0.93 | FKBP1A (0.49) | ALDH1A1FKBP1AFABP7FABP5TDP1 | |
| SCHEMBL9352596 | 0.93 | FKBP1A (0.49) | ALDH1A1FKBP1AFABP7FABP5TDP1 | |
| SCHEMBL9352930 | 0.93 | FKBP1A (0.49) | ALDH1A1FKBP1AFABP7FABP5TDP1 | |
| SCHEMBL9352909 | 0.91 | KMT2A (0.50) | ALDH1A1FKBP1ATDP1L3MBTL1KMT2A | |
| SCHEMBL9356467 | 0.91 | KMT2A (0.50) | ALDH1A1FKBP1ATDP1L3MBTL1KMT2A | |
| SCHEMBL9356472 | 0.91 | KMT2A (0.50) | ALDH1A1FKBP1ATDP1L3MBTL1KMT2A | |
| SCHEMBL9356134 | 0.87 | ALDH1A1 (0.47) | ALDH1A1FKBP1AFABP7FABP5TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014011863-A1 | METHOD OF TREATMENT WITH 3-CYCLOPROPYLCARBONYL-3,6-DIAZABICYCLO[3.1.1]HEPTANE | TARGACEPT, INC. (US) | 2014-01-16 | — | — | WO | disclosed |
| WO-2012125518-A1 | SALT FORMS OF 3 - CYCLOPROPYLCARBONYL - 3, 6 - DIAZABICYCLO [3.1.1] HEPTANE | TARGACEPT, INC. (US) | 2012-09-20 | — | — | WO | disclosed |
| EP-0299513-B1 | Azetidine derivatives, compositions and their use | FIDIA GEORGETOWN INST (US) | 1994-10-05 | — | — | EP | disclosed |
| US-4990504-A | Modulate excitatory amino acid receptor system | FIDIA-GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) | 1991-02-05 | — | — | US | disclosed |
| US-4946839-A | ALZHEIMER'S DISEASE | FIDIA-GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) | 1990-08-07 | — | — | US | disclosed |
| EP-0299513-A1 | Azetidine derivatives, compositions and their use | FIDIA-GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) | 1989-01-18 | — | — | EP | disclosed |