SCHEMBL9356554

SCHEMBL9356554

C[Si](C)(CCCC(=O)Cl)O[Si](C)(C)CCCC(=O)Cl

nearest known ligand 0.46

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.46
TP53 P04637 1/20 0.46
TSHR P16473 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11148347 0.86 TSHR (0.42) ALDH1A1TP53TSHR
SCHEMBL512941 0.79 TSHR (0.48) ALDH1A1TSHR
SCHEMBL18227267 0.79 TSHR (0.33) ALDH1A1TP53TSHR
SCHEMBL11151060 0.78 ALDH1A1 (0.52) ALDH1A1TP53TSHR
SCHEMBL11205937 0.78 ALDH1A1 (0.52) ALDH1A1TP53TSHR
Hydrochloric Acid SCHEMBL7534254 0.77 TSHR (0.46) ALDH1A1TSHR
Hydrochloric Acid SCHEMBL5368847 0.77 TSHR (0.46) ALDH1A1TSHR
SCHEMBL13104746 0.77 TSHR (0.53) ALDH1A1TP53TSHR
SCHEMBL10894480 0.76 ALDH1A1 (0.50) ALDH1A1TP53TSHR
SCHEMBL9066514 0.76 ALDH1A1 (0.50) ALDH1A1TP53TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220184104-A1 SILANOL BASED THERAPEUTIC PAYLOADS BLINKBIO INC (US) 2022-06-16 US disclosed
US-20210161921-A1 Silanol Based Therapeutic Payloads BLINKBIO, INC. 2021-06-03 US disclosed
US-10716801-B2 Silanol based therapeutic payloads BLINKBIO, INC. (US) 2020-07-21 US disclosed
US-20190183913-A1 Silanol Based Therapeutic Payloads BLINKBIO INC (US) 2019-06-20 US disclosed
US-10293053-B2 Silanol based therapeutic payloads BLINKBIO, INC. (US) 2019-05-21 US disclosed
US-20190111142-A1 Silanol Based Therapeutic Payloads BLINKBIO, INC. (US) 2019-04-18 US disclosed
US-20180200273-A1 Silanol Based Therapeutic Payloads BLINKBIO INC (US) 2018-07-19 US disclosed
US-20180200273-A1 Silanol Based Therapeutic Payloads BLINKBIO INC (US) 2018-07-19 US disclosed
EP-0254556-B1 Semipermeable thin-film membranes comprising siloxane, alkoxysilyl and aryloxysilyl oligomers and copolymers BEND RES INC (US) 1994-11-17 EP disclosed
US-4781733-A GAS SEPARATION, POLYCONDENSATION OF POLYFUNCTIONAL COMPOUNDS BEND RESEARCH, INC. (US) 1988-11-01 US disclosed
EP-0254556-A2 Semipermeable thin-film membranes comprising siloxane, alkoxysilyl and aryloxysilyl oligomers and copolymers BEND RESEARCH, INC. (US) 1988-01-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190183913-A1 Silanol Based Therapeutic Payloads CD47, CD4, BST2 ALDH1A1 1176/4885TP53 26/4885TSHR 3437/4885
US-20210161921-A1 Silanol Based Therapeutic Payloads CD47, CD4, BST2 ALDH1A1 1176/4885TP53 26/4885TSHR 3437/4885
US-10716801-B2 Silanol based therapeutic payloads CD47, CD4, BST2 ALDH1A1 1176/4885TP53 26/4885TSHR 3437/4885
US-20180200273-A1 Silanol Based Therapeutic Payloads CD47, CD4, BST2 ALDH1A1 1176/4885TP53 26/4885TSHR 3437/4885
US-10293053-B2 Silanol based therapeutic payloads CD47, CD4, BST2 ALDH1A1 1176/4885TP53 26/4885TSHR 3437/4885
US-20190111142-A1 Silanol Based Therapeutic Payloads CD47, CD4, BST2 ALDH1A1 1176/4885TP53 26/4885TSHR 3437/4885
US-20220184104-A1 SILANOL BASED THERAPEUTIC PAYLOADS CD47, CD4, BST2 ALDH1A1 1176/4885TP53 26/4885TSHR 3437/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.