Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 13/20 | 0.66 |
| ▸ | NPC1 | O15118 | 12/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.61 |
| ▸ | RELA | Q04206 | 3/20 | 0.61 |
| ▸ | BUB1 | O43683 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20542549 | 0.85 | NPC1 (0.55) | RAB9ANPC1SMN1; SMN2LMNANFKB1 | |
| SCHEMBL3278505 | 0.84 | NPC1 (0.77) | RAB9ANPC1SMN1; SMN2LMNANFKB1 | |
| SCHEMBL6905520 | 0.82 | NPC1 (0.67) | RAB9ANPC1SMN1; SMN2LMNANFKB1 | |
| SCHEMBL6951826 | 0.81 | BUB1 (0.56) | RAB9ANPC1SMN1; SMN2LMNANFKB1 | |
| SCHEMBL5467090 | 0.80 | RORC (0.49) | RAB9ANPC1SMN1; SMN2LMNANFKB1 | |
| SCHEMBL1819335 | 0.80 | NPC1 (1.00) | RAB9ANPC1SMN1; SMN2LMNANFKB1 | |
| SCHEMBL3266299 | 0.80 | NPC1 (0.71) | RAB9ANPC1SMN1; SMN2LMNANFKB1 | |
| SCHEMBL30073965 | 0.78 | NPC1 (0.78) | RAB9ANPC1SMN1; SMN2LMNANFKB1 | |
| SCHEMBL3112891 | 0.78 | NPC1 (0.78) | RAB9ANPC1SMN1; SMN2LMNANFKB1 | |
| SCHEMBL15921022 | 0.76 | BUB1 (1.00) | RAB9ANPC1SMN1; SMN2LMNANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282971-B1 | Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents | WARNER LAMBERT CO (US) | 1994-12-28 | — | — | EP | disclosed |
| US-4971983-A | Use as anesthetics in surgery where a risk of cerebrovascular damage exists; e.g. riluzole | WARNER-LAMBERT COMPANY (US) | 1990-11-20 | — | — | US | disclosed |
| US-4918090-A | ADMINISTERING TO STROKE PATIENT | WARNER-LAMBERT COMPANY (US) | 1990-04-17 | — | — | US | disclosed |
| US-4826860-A | STROKES | WARNER-LAMBERT COMPANY (US) | 1989-05-02 | — | — | US | disclosed |