Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Butyl Fumarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 8/20 | 1.00 |
| ▸ | ATM | Q13315 | 1/20 | 0.83 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyl Fumarate SCHEMBL43165 | 1.00 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Maleic Acid SCHEMBL28199237 | 1.00 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL43164 | 1.00 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL4376900 | 1.00 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL124163 | 1.00 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Maleic Acid SCHEMBL27358295 | 1.00 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL29604195 | 1.00 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL6905849 | 0.98 | HCAR2 (0.96) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL1223794 | 0.98 | HCAR2 (0.96) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL18628256 | 0.98 | HCAR2 (0.96) | HCAR2ATMMAPTRAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1181402-C | Tuning agent for electrostatic image development and thermal fixation | 佳能株式会社 | 2004-12-22 | — | — | CN | disclosed |
| CN-1087840-C | Toner for developing electrostatic image and thermal alignment method using the same | CANON KK (JP) | 2002-07-17 | — | — | CN | disclosed |
| CN-1313528-A | Tuning agent for electrostatic image development and thermal fixation | CANON KK (JP) | 2001-09-19 | — | — | CN | disclosed |
| CN-1070490-A | Toner for developing electrostatic image and heat-fixing | CANON KK (JP) | 1993-03-31 | — | — | CN | disclosed |