Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9359151 | 0.93 | HTT (0.47) | HSD17B10NPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL7642011 | 0.90 | HTT (0.45) | HSD17B10NPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL9359324 | 0.89 | KDM4E (0.46) | HTT | |
| SCHEMBL9240842 | 0.86 | NPC1 (0.47) | HSD17B10NPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL9363467 | 0.83 | KDM4E (0.47) | — | |
| SCHEMBL9359237 | 0.82 | NPC1 (0.40) | NPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL9155117 | 0.80 | NPC1 (0.42) | NPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL9359150 | 0.80 | PKM (0.46) | HSD17B10NPC1 | |
| SCHEMBL9359029 | 0.80 | RECQL (0.45) | HSD17B10NPC1HTT | |
| SCHEMBL9177141 | 0.78 | TACR1 (0.50) | HSD17B10NPC1HTTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421456-B1 | Quinoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-12-28 | — | — | EP | claimed |
| US-5223513-A | Anticholesterol agent | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-06-29 | — | — | US | claimed |
| EP-0421456-A2 | Quinoline derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-04-10 | — | — | EP | claimed |
| EP-0421456-B1 | Quinoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-12-28 | — | — | EP | disclosed |
| US-5223513-A | Anticholesterol agent | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-06-29 | — | — | US | disclosed |
| EP-0421456-A2 | Quinoline derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-04-10 | — | — | EP | disclosed |