Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.44 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9358633 | 0.83 | HRH3 (0.39) | GSK3BALDH1A1BCHEACHESIGMAR1 | |
| SCHEMBL5256493 | 0.83 | EHMT2 (0.38) | GSK3BEHMT2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL21803243 | 0.79 | GSK3B (0.44) | GSK3BEHMT2PPARGTP53SMN1; SMN2 | |
| SCHEMBL29106717 | 0.79 | GSK3B (0.44) | GSK3BEHMT2PPARGTP53SMN1; SMN2 | |
| SCHEMBL9305366 | 0.79 | ALDH1A1 (0.37) | GSK3BPPARGSMN1; SMN2KDM1AALDH1A1 | |
| SCHEMBL31571120 | 0.79 | ALDH1A1 (0.37) | GSK3BPPARGSMN1; SMN2KDM1AALDH1A1 | |
| Iodide SCHEMBL28993212 | 0.78 | GSK3B (0.43) | GSK3BEHMT2PPARGTP53SMN1; SMN2 | |
| SCHEMBL29221320 | 0.76 | GSK3B (0.45) | GSK3BEHMT2PPARGTP53SMN1; SMN2 | |
| SCHEMBL6936002 | 0.73 | BCHE (0.41) | PPARGSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL25381130 | 0.73 | PPARG (0.42) | GSK3BEHMT2PPARGTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282971-B1 | Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents | WARNER LAMBERT CO (US) | 1994-12-28 | — | — | EP | disclosed |
| US-4971983-A | Use as anesthetics in surgery where a risk of cerebrovascular damage exists; e.g. riluzole | WARNER-LAMBERT COMPANY (US) | 1990-11-20 | — | — | US | disclosed |
| US-4918090-A | ADMINISTERING TO STROKE PATIENT | WARNER-LAMBERT COMPANY (US) | 1990-04-17 | — | — | US | disclosed |
| US-4826860-A | STROKES | WARNER-LAMBERT COMPANY (US) | 1989-05-02 | — | — | US | disclosed |
| EP-0282971-A2 | Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents | WARNER-LAMBERT COMPANY (US) | 1988-09-21 | — | — | EP | disclosed |