Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | ALPL | P05186 | 1/20 | 0.54 |
| ▸ | CD74 | P04233 | 1/20 | 0.51 |
| ▸ | MIF | P14174 | 1/20 | 0.51 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.49 |
| ▸ | HPGDS | O60760 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.48 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.48 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17336859 | 0.88 | RAB9A (0.62) | BCHEACHERAB9APOLBCD74 | |
| SCHEMBL1505323 | 0.87 | MAP2K4 (0.55) | BCHEACHERAB9APOLBCA12 | |
| SCHEMBL26477869 | 0.84 | RAF1 (0.55) | BCHEACHERAB9APOLBCD74 | |
| SCHEMBL936143 | 0.84 | PRKD1 (0.54) | BCHEACHEAPPRAB9AALPL | |
| SCHEMBL12172053 | 0.84 | BCHE (0.54) | BCHEACHERAB9APOLBCD74 | |
| SCHEMBL1180980 | 0.83 | APP (0.62) | APPRAB9APOLBHPGDSMAPK1 | |
| SCHEMBL13885580 | 0.83 | RAB9A (0.79) | APPRAB9APOLBCA12ALPL | |
| SCHEMBL17279935 | 0.81 | RAB9A (0.60) | BCHEACHERAB9APOLBPRKD1 | |
| SCHEMBL936452 | 0.81 | PRKD1 (0.74) | BCHEACHEAPPPRKD1 | |
| SCHEMBL1505270 | 0.80 | PRKD1 (0.50) | BCHEACHERAB9APOLBCD74 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |