SCHEMBL9360940

SCHEMBL9360940

COc1ccc(/C=C(\C#N)C(=O)O)c(OC)c1

nearest known ligand 0.78

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.78
CYP3A4 P08684 1/20 0.78
CYP2C9 P11712 1/20 0.78
SLC16A3 O15427 7/20 0.69
SLC16A1 P53985 7/20 0.69
KMT2A Q03164 2/20 0.68
KDM4E B2RXH2 1/20 0.68
LMNA P02545 1/20 0.68
PKM P14618 1/20 0.68
ALDH1A1 P00352 3/20 0.52
MAPT P10636 2/20 0.52
MEN1 O00255 1/20 0.52
CYP1A1 P04798 1/20 0.50
CYP1B1 Q16678 1/20 0.50
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8649661 1.00 CYP1A2 (0.78) CYP1A2CYP3A4CYP2C9SLC16A3SLC16A1
SCHEMBL15428904 0.89 KDM4E (0.68) CYP1A2CYP3A4CYP2C9SLC16A3SLC16A1
SCHEMBL23605194 0.87 EGFR (0.60) CYP1A2CYP3A4CYP2C9SLC16A3SLC16A1
SCHEMBL9658963 0.86 PKM (0.68) CYP1A2CYP3A4CYP2C9SLC16A3SLC16A1
SCHEMBL3020683 0.86 CYP1A2 (0.58) CYP1A2CYP3A4CYP2C9SLC16A3SLC16A1
SCHEMBL17831051 0.86 KDM4E (0.68) CYP1A2CYP3A4CYP2C9SLC16A3SLC16A1
SCHEMBL3020681 0.86 CYP1A2 (0.58) CYP1A2CYP3A4CYP2C9SLC16A3SLC16A1
SCHEMBL9658958 0.86 PKM (0.68) CYP1A2CYP3A4CYP2C9SLC16A3SLC16A1
SCHEMBL22635883 0.84 KDM4E (0.66) CYP1A2CYP3A4CYP2C9SLC16A3SLC16A1
SCHEMBL22635882 0.84 KDM4E (0.66) CYP1A2CYP3A4CYP2C9SLC16A3SLC16A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0335641-B1 Organic nonlinear optical substance TEIJIN LTD (JP) 1994-01-05 EP disclosed
US-5196147-A Optical crystals TEIJIN LIMITED (JP) 1993-03-23 US disclosed
EP-0335641-A2 Organic nonlinear optical substance TEIJIN LIMITED (JP) 1989-10-04 EP disclosed