SCHEMBL9362014

SCHEMBL9362014

C=CC=CC(=C(C#N)C(=O)O)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.41
MAPT P10636 4/20 0.41
LMNA P02545 4/20 0.41
MAPK1 P28482 3/20 0.41
RAB9A P51151 2/20 0.41
NPSR1 Q6W5P4 2/20 0.41
XBP1 P17861 1/20 0.41
AKT1 P31749 1/20 0.39
L3MBTL1 Q9Y468 3/20 0.36
RECQL P46063 2/20 0.34
TDP1 Q9NUW8 2/20 0.34
POLB P06746 1/20 0.34
CYP3A4 P08684 1/20 0.34
PARP1 P09874 1/20 0.34
TSHR P16473 1/20 0.34
CYP2C19 P33261 1/20 0.34
BLM P54132 1/20 0.34
PMP22 Q01453 1/20 0.34
HSD17B10 Q99714 1/20 0.34
KMT2A Q03164 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9362180 0.83 AKT1 (0.48) ALDH1A1MAPTLMNAMAPK1RAB9A
SCHEMBL9508911 0.75 AKT1 (0.38) ALDH1A1MAPTLMNAMAPK1RAB9A
SCHEMBL10938243 0.75 AKT1 (0.40) ALDH1A1MAPTLMNAMAPK1RAB9A
SCHEMBL1552201 0.74 AKT1 (0.33) ALDH1A1MAPTLMNARAB9ANPSR1
SCHEMBL251132 0.74 AKT1 (0.33) ALDH1A1MAPTLMNANPSR1AKT1
SCHEMBL18833161 0.73 AKT1 (0.39) ALDH1A1MAPTLMNAMAPK1RAB9A
SCHEMBL7489107 0.72 TSHR (0.44) ALDH1A1MAPTLMNAMAPK1AKT1
Acrylonitrile SCHEMBL28123112 0.72 TSHR (0.35) ALDH1A1MAPTLMNAMAPK1RAB9A
Ethylene SCHEMBL28481468 0.72 ALDH1A1 (0.47) ALDH1A1MAPTLMNAMAPK1RAB9A
SCHEMBL26391230 0.72 AKT1 (0.38) ALDH1A1MAPTLMNARAB9AAKT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0335641-B1 Organic nonlinear optical substance TEIJIN LTD (JP) 1994-01-05 EP disclosed
US-5196147-A Optical crystals TEIJIN LIMITED (JP) 1993-03-23 US disclosed
EP-0335641-A2 Organic nonlinear optical substance TEIJIN LIMITED (JP) 1989-10-04 EP disclosed