Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.63 |
| ▸ | CCR1 | P32246 | 1/20 | 0.56 |
| ▸ | CCR5 | P51681 | 1/20 | 0.56 |
| ▸ | CCR8 | P51685 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 4/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | ERN1 | O75460 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | CTSB | P07858 | 2/20 | 0.48 |
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6537968 | 0.86 | ALDH1A1 (0.61) | MEN1KMT2AALDH1A1KDM4ETDP1 | |
| SCHEMBL26964175 | 0.78 | ALDH1A1 (0.58) | MEN1KMT2AALDH1A1KDM4ETDP1 | |
| SCHEMBL31067265 | 0.78 | ALDH1A1 (0.67) | MEN1KMT2AALDH1A1KDM4ETDP1 | |
| SCHEMBL22120229 | 0.78 | ALDH1A1 (0.67) | MEN1KMT2AALDH1A1KDM4ETDP1 | |
| SCHEMBL317836 | 0.78 | KMT2A (1.00) | MEN1KMT2AALDH1A1KDM4ETDP1 | |
| SCHEMBL6538214 | 0.78 | MAPT (0.77) | MEN1KMT2AALDH1A1KDM4ETDP1 | |
| SCHEMBL4642926 | 0.78 | MEN1 (0.67) | MEN1KMT2AALDH1A1KDM4ETDP1 | |
| SCHEMBL29800698 | 0.78 | ALDH1A1 (0.67) | MEN1KMT2AALDH1A1KDM4ETDP1 | |
| SCHEMBL27190190 | 0.77 | MAPT (0.74) | MEN1KMT2AALDH1A1KDM4ETDP1 | |
| SCHEMBL1394957 | 0.76 | TDP1 (0.69) | ALDH1A1TDP1MAPTSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1025854-C | Process for preparing quinolyl oxazol-2-ones | MERRELL DOW PHARMA (US) | 1994-09-07 | — | — | CN | disclosed |
| EP-0365863-B1 | Novel quinolyloxazole-2-ones useful as proteinkinase C inhibitors | MERRELL DOW PHARMA (US) | 1994-08-17 | — | — | EP | disclosed |
| EP-0428105-B1 | Use of quinolyl- and isoquinolyloxazole-2-ones for the production of a medicament for the prevention of glycoprotein enveloped virus infectivity | MERRELL DOW PHARMA (US) | 1994-01-19 | — | — | EP | disclosed |
| EP-0428107-B1 | Use of quinolyl-and isoquinolyloxanole-2-ones for the production of a medicament for the treatment of multi-drug resistant tumors | MERRELL DOW PHARMA (US) | 1994-01-19 | — | — | EP | disclosed |
| US-5190957-A | TREATMENT OF MULTI-DRUG RESISTANT TUMORS WITH QUINOLYL-AND ISOQUINOLYLOXAZOLE-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-03-02 | — | — | US | disclosed |
| US-5061715-A | Useful in treating AIDS and ARC | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-10-29 | — | — | US | disclosed |
| EP-0428107-A2 | Use of quinolyl-and isoquinolyloxanole-2-ones for the production of a medicament for the treatment of multi-drug resistant tumors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-05-22 | — | — | EP | disclosed |
| EP-0428105-A2 | Use of quinolyl- and isoquinolyloxazole-2-ones for the production of a medicament for the prevention of glycoprotein enveloped virus infectivity | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-05-22 | — | — | EP | disclosed |
| US-4999431-A | Reacting A Bromoquinoline Compound With Butyllithium And An N-Methyl-N-Methoxyalkanamide; Intermediates for Quinolyloxazole-2-ones | MERRELL DOW PHARMACEUTICALS (US) | 1991-03-12 | — | — | US | disclosed |
| US-4990519-A | Antiasthma, hypotensive agents, bronchodilator agents | MERRELL DOW PHARMACEUTICALS (US) | 1991-02-05 | — | — | US | disclosed |
| CN-1042145-A | New quinolyl azoles-2-ketone compounds as inhibitors of protein kinase C | MERRELL DOW PHARMA (US) | 1990-05-16 | — | — | CN | disclosed |
| EP-0365863-A2 | Novel quinolyloxazole-2-ones useful as proteinkinase C inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-05-02 | — | — | EP | disclosed |
| US-4886811-A | HYPOTENSIVE AGENTS AND VASODILATORS | MERRELL DOW PHARMACEUTICALS (US) | 1989-12-12 | — | — | US | disclosed |