Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 8/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | SHBG | P04278 | 2/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2813805 | 0.91 | ESR1 (0.47) | AKR1C3ESR1ESR2CYP19A1HSD17B1 | |
| SCHEMBL30940153 | 0.91 | ESR1 (0.47) | AKR1C3ESR1ESR2CYP19A1HSD17B1 | |
| SCHEMBL2813791 | 0.88 | AKR1C3 (0.42) | AKR1C3ESR1ESR2HSD17B1MEN1 | |
| SCHEMBL2812915 | 0.88 | NQO2 (0.48) | AKR1C3ESR1ESR2CYP19A1CA1 | |
| SCHEMBL23670494 | 0.86 | P2RX7 (0.46) | AKR1C3HTR2B | |
| SCHEMBL19469653 | 0.86 | P2RX7 (0.46) | AKR1C3HTR2B | |
| SCHEMBL19285262 | 0.86 | P2RX7 (0.46) | AKR1C3HTR2B | |
| SCHEMBL29552779 | 0.86 | P2RX7 (0.46) | AKR1C3HTR2B | |
| SCHEMBL1530291 | 0.83 | SRD5A1 (0.44) | AKR1C3MAPTSLC6A4SLC6A3 | |
| SCHEMBL19469507 | 0.83 | MTNR1A (0.50) | CYP19A1CA1CA2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249179-A1 | Farnesoid X Receptor Agonists | SMITHKLINE BEECHAM CORPORATION (US) | 2010-09-30 | — | — | US | disclosed |
| EP-0275104-B1 | Process for preparing 2,3-dihydro-1H-imidazolylalkoxyindene derivatives and pharmaceutically acceptable salts, and intermediate therefor | FERRER INT (ES) | 1994-01-19 | — | — | EP | disclosed |
| US-4843165-A | Process for preparing a 2,3-dihydro-1H-imidazolyl-ethoxy indene antithrombotic agent and its pharmaceutically acceptable salts | FERRER INTERNACIONAL S.A. (ES) | 1989-06-27 | — | — | US | disclosed |
| EP-0275104-A2 | Process for preparing 2,3-dihydro-1H-imidazolylalkoxyindene derivatives and pharmaceutically acceptable salts, and intermediate therefor | FERRER INTERNACIONAL, S.A. (ES) | 1988-07-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249179-A1 | Farnesoid X Receptor Agonists | NR1H4, NR1H3, NR1H2 | AKR1C3 510/4885ESR1 451/4885ESR2 251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.