Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 4/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 4/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9365335 | 0.88 | GRIA1 (0.45) | GRIA1GRIA2GRIA3GRIA4CYP1A2 | |
| SCHEMBL9364720 | 0.84 | L3MBTL1 (0.40) | GRIA1GRIA2GRIA3GRIA4CYP1A2 | |
| SCHEMBL9091900 | 0.84 | GRIA1 (0.40) | GRIA1GRIA2GRIA3GRIA4KDM4E | |
| SCHEMBL9365531 | 0.78 | FASN (0.44) | DAO | |
| SCHEMBL9362677 | 0.74 | KDM4E (0.40) | MAOAMAOBKDM4E | |
| SCHEMBL9364622 | 0.74 | GRIN2D (0.58) | GRIA1GRIA2GRIA3GRIA4DAO | |
| SCHEMBL4704409 | 0.74 | GRIA1 (0.64) | GRIA1GRIA2GRIA3GRIA4CYP1A2 | |
| SCHEMBL9971326 | 0.73 | GRIA1 (0.63) | GRIA1GRIA2GRIA3GRIA4CYP1A2 | |
| SCHEMBL9364640 | 0.72 | DAO (0.39) | GRIA1GRIA2GRIA3GRIA4DAO | |
| SCHEMBL9368432 | 0.70 | GRIN2D (0.56) | DAOGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0377112-B1 | Quinoxaline compounds and their preparation and use | NOVO NORDISK AS (DK) | 1994-08-24 | — | — | EP | disclosed |
| US-5061706-A | 2,3-QUINOXALINEDIONES FOR USE AS NEUROLEPTICS | NOVO NORDISK A/S (DK) | 1991-10-29 | — | — | US | disclosed |
| EP-0377112-A1 | Quinoxaline compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1990-07-11 | — | — | EP | disclosed |