Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.66 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.66 |
| ▸ | CA1 | P00915 | 4/20 | 0.58 |
| ▸ | CA2 | P00918 | 4/20 | 0.58 |
| ▸ | GFER | P55789 | 2/20 | 0.55 |
| ▸ | MPO | P05164 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | KDM5A | P29375 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | PTPRC | P08575 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL936016 | 0.93 | HIF1A (0.69) | HIF1AKDM4EMAPTSLC22A6SLC22A8 | |
| SCHEMBL11175012 | 0.86 | HIF1A (0.61) | HIF1AKDM4EMAPTSLC22A6SLC22A8 | |
| SCHEMBL13593287 | 0.86 | HIF1A (0.61) | HIF1AKDM4EMAPTSLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL28065222 | 0.85 | MAPT (0.65) | HIF1AKDM4EMAPTSLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL28828011 | 0.85 | MAPT (0.65) | HIF1AKDM4EMAPTSLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL8957458 | 0.85 | HIF1A (0.59) | HIF1AKDM4EMAPTSLC22A6SLC22A8 | |
| SCHEMBL11107537 | 0.84 | KDM4E (0.80) | HIF1AKDM4EMAPTSLC22A6SLC22A8 | |
| Benzoic Acid SCHEMBL15670619 | 0.83 | HIF1A (0.57) | HIF1AKDM4EMAPTSLC22A6SLC22A8 | |
| SCHEMBL19634406 | 0.80 | KDM4E (0.68) | HIF1AKDM4EMAPTSLC22A6SLC22A8 | |
| Aminohippuric Acid SCHEMBL196513 | 0.79 | KDM4E (1.00) | HIF1AKDM4EMAPTSLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011010103-A1 | METHODS AND USES | IMPERIAL INNOVATIONS LIMITED (GB) | 2011-01-27 | — | — | WO | disclosed |