Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9365478 | 0.89 | MAPT (0.67) | ALDH1A1KMT2AMAPTLMNACYP1A2 | |
| SCHEMBL6004947 | 0.87 | CYP1A2 (0.65) | ALDH1A1KMT2AMAPTNPC1LMNA | |
| SCHEMBL9364514 | 0.87 | KMT2A (0.58) | ALDH1A1KMT2AMAPTNPC1LMNA | |
| SCHEMBL9365284 | 0.87 | PKM (0.59) | ALDH1A1KMT2AMAPTLMNAMAPK1 | |
| SCHEMBL8135626 | 0.87 | ALDH1A1 (0.58) | ALDH1A1KMT2AMAPTNPC1LMNA | |
| SCHEMBL9365386 | 0.87 | ALDH1A1 (0.58) | ALDH1A1KMT2AMAPTNPC1LMNA | |
| SCHEMBL4812667 | 0.86 | MAPT (0.69) | ALDH1A1KMT2AMAPTNPC1LMNA | |
| SCHEMBL2800656 | 0.86 | KMT2A (0.62) | ALDH1A1KMT2AMAPTNPC1LMNA | |
| SCHEMBL9365311 | 0.85 | KMT2A (0.56) | ALDH1A1KMT2AMAPTNPC1LMNA | |
| SCHEMBL9364781 | 0.85 | ALDH1A1 (0.59) | ALDH1A1KMT2AMAPTNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0377112-B1 | Quinoxaline compounds and their preparation and use | NOVO NORDISK AS (DK) | 1994-08-24 | — | — | EP | disclosed |
| US-5061706-A | 2,3-QUINOXALINEDIONES FOR USE AS NEUROLEPTICS | NOVO NORDISK A/S (DK) | 1991-10-29 | — | — | US | disclosed |
| EP-0377112-A1 | Quinoxaline compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1990-07-11 | — | — | EP | disclosed |