Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | GPR132 | Q9UNW8 | 9/20 | 0.53 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.47 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9366692 | 0.84 | MAPK1 (0.53) | MAPK1GPR132CMKLR2CMKLR1SMN1; SMN2 | |
| SCHEMBL16032268 | 0.84 | GPR132 (0.51) | MAPK1GPR132 | |
| Hydrochloric Acid SCHEMBL9370032 | 0.83 | CYSLTR1 (0.64) | MAPK1SMN1; SMN2KMT2ALMNAALDH1A1 | |
| SCHEMBL8403515 | 0.83 | GPR132 (0.44) | GPR132HTT | |
| SCHEMBL10956292 | 0.83 | SMN1; SMN2 (0.59) | MAPK1GPR132CMKLR2CMKLR1SMN1; SMN2 | |
| SCHEMBL10638843 | 0.82 | MAPK1 (0.57) | MAPK1GPR132SMN1; SMN2KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL10360468 | 0.81 | MAPK1 (0.56) | MAPK1GPR132SMN1; SMN2KMT2ALMNA | |
| SCHEMBL16032640 | 0.81 | GPR132 (0.56) | GPR132CMKLR2CMKLR1 | |
| SCHEMBL9367149 | 0.81 | HIF1A (0.44) | GPR132SMN1; SMN2LMNATSHR | |
| SCHEMBL9577515 | 0.79 | CYP4F2 (0.59) | MAPK1SMN1; SMN2KMT2ALMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0391624-B1 | Substituted 1-[3-heteroarylmethoxy)phenyl] alkanols and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER (US) | 1994-04-06 | — | — | EP | disclosed |
| US-5248685-A | Substituted 1-[3-(heteroarylmethoxy)phenyl]alkanols and related compounds in the treatment of asthma | PFIZER INC. (US) | 1993-09-28 | — | — | US | disclosed |
| WO-1990012006-A1 | SUBSTITUTED 1-[3-(HETEROARYLMETHOXY)PHENYL]ALKANOLS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1990-10-18 | — | — | WO | disclosed |
| EP-0391624-A1 | Substituted 1-[3-heteroarylmethoxy)phenyl] alkanols and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1990-10-10 | — | — | EP | disclosed |