Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499451 | 0.82 | HIF1A (0.51) | HIF1AADRB2ADRB1HTR1AADRA2A | |
| SCHEMBL7871790 | 0.82 | HIF1A (0.51) | HIF1AADRB2ADRB1HTR1AADRA2A | |
| SCHEMBL9366388 | 0.81 | MAPK1 (0.55) | TSHRLMNASMN1; SMN2GPR132 | |
| SCHEMBL16030438 | 0.79 | CHRNA7 (0.53) | ADRB2ADRB1ADRB3SLC6A3KDM4E | |
| SCHEMBL6963546 | 0.79 | CYP2D6 (0.53) | HIF1ATSHRSLC6A3CYP19A1 | |
| SCHEMBL11071679 | 0.78 | CHRNA7 (0.53) | DRD1CHRNA7PTAFRESR1CYP19A1 | |
| SCHEMBL6962168 | 0.76 | CYP11B1 (0.46) | TSHRRAB9ALMNAKDM4ECHRNA7 | |
| SCHEMBL8403515 | 0.76 | GPR132 (0.44) | GPR132 | |
| SCHEMBL23655466 | 0.74 | CHRNA7 (0.57) | KDM4ECHRNA7CYP2A6L3MBTL1TDP1 | |
| SCHEMBL5016747 | 0.74 | CHRNA7 (0.57) | KDM4ECHRNA7CYP2A6L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0391624-B1 | Substituted 1-[3-heteroarylmethoxy)phenyl] alkanols and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER (US) | 1994-04-06 | — | — | EP | disclosed |
| US-5248685-A | Substituted 1-[3-(heteroarylmethoxy)phenyl]alkanols and related compounds in the treatment of asthma | PFIZER INC. (US) | 1993-09-28 | — | — | US | disclosed |
| WO-1990012006-A1 | SUBSTITUTED 1-[3-(HETEROARYLMETHOXY)PHENYL]ALKANOLS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1990-10-18 | — | — | WO | disclosed |
| EP-0391624-A1 | Substituted 1-[3-heteroarylmethoxy)phenyl] alkanols and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1990-10-10 | — | — | EP | disclosed |