Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 5/20 | 0.35 |
| ▸ | CA2 | P00918 | 5/20 | 0.35 |
| ▸ | CA9 | Q16790 | 5/20 | 0.35 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9362850 | 0.90 | CA12 (0.38) | HTTAKT1AKT2TNFPTGS2 | |
| SCHEMBL3342309 | 0.85 | HTT (0.40) | HTTAKT1AKT2CA1CA2 | |
| SCHEMBL9367773 | 0.85 | DYRK1A (0.38) | HTTAKT1AKT2TNFPTGS2 | |
| SCHEMBL3342795 | 0.84 | AKT1 (0.40) | HTTAKT1AKT2PTGS2CA1 | |
| SCHEMBL3343151 | 0.82 | AKT1 (0.39) | HTTAKT1AKT2CA1CA2 | |
| SCHEMBL3346028 | 0.82 | CHRNA7 (0.35) | TNFPTGS2 | |
| SCHEMBL3343016 | 0.81 | PDE10A (0.40) | HTTAKT1AKT2PTGS2PTGS1 | |
| SCHEMBL2065760 | 0.80 | TNF (0.35) | AKT1AKT2TNFCA1CA2 | |
| SCHEMBL2065746 | 0.77 | PDE10A (0.37) | TNFCA1CA2CA12CA7 | |
| SCHEMBL3157242 | 0.77 | TNF (0.54) | AKT1AKT2TNFMKNK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0305939-B1 | Process of producing sulfonylurea derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-11-02 | — | — | EP | disclosed |
| US-4994571-A | Reacting heterocycle-containing sulfonamide compound with carbonyl compound | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-02-19 | — | — | US | disclosed |
| EP-0305939-A1 | Process of producing sulfonylurea derivatives | Takeda Chemical Industries, Ltd. (JP) | 1989-03-08 | — | — | EP | disclosed |