Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9371037 | 0.85 | GPR35 (0.41) | ALDH1A1L3MBTL1GPR35PKMNPSR1 | |
| SCHEMBL9368107 | 0.82 | ALDH1A1 (0.46) | ALDH1A1NPSR1TP53MAPTHPGD | |
| SCHEMBL3055938 | 0.82 | ALDH1A1 (0.33) | ALDH1A1L3MBTL1NPSR1TP53MAPT | |
| SCHEMBL1760858 | 0.80 | GPR35 (0.49) | ALDH1A1GPR35HPGDPTPN1HSD17B10 | |
| SCHEMBL2761037 | 0.80 | CA1 (0.39) | ALDH1A1MAPTHPGDTSHRKDM4E | |
| SCHEMBL9365766 | 0.79 | ALDH1A1 (0.31) | ALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL11597062 | 0.78 | CA1 (0.38) | ALDH1A1MAPTHPGDTSHRKDM4E | |
| SCHEMBL9365753 | 0.77 | RXFP1 (0.40) | ALDH1A1L3MBTL1GPR35PKMNPSR1 | |
| SCHEMBL4062814 | 0.76 | GRIA2 (0.36) | ALDH1A1L3MBTL1GPR35PKMNPSR1 | |
| SCHEMBL16311870 | 0.75 | GPR35 (0.50) | ALDH1A1GPR35PKMNPSR1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1025027-C | Organic compounds and their use as pharmaceuticals | LILLY SA (ES) | 1994-06-15 | — | — | CN | disclosed |
| EP-0368464-B1 | Thiopene-2 carboxamide derivatives and their pharmaceutical use | LILLY SA (ES) | 1994-02-02 | — | — | EP | disclosed |
| EP-0297697-B1 | Thiophene-2-carboxamide derivatives and their pharmaceutical use | LILLY SA (ES) | 1993-12-29 | — | — | EP | disclosed |
| US-5021449-A | N-pyrrolidinyl-3 alkyloxythienyl-2-carboxamides; antiemetics, antidepressants, schizophrenia | LILLY S.A. (ES) | 1991-06-04 | — | — | US | disclosed |
| EP-0249236-B1 | N-1H-TETRAZOL-5-YL-(5-RING)-CARBOXAMIDE-DERIVATIVES, A PROCESS FOR THEIR MANUFACTURE, AND THE USE THEREOF | WARNER-LAMBERT COMPANY (US) | 1991-04-24 | — | — | EP | disclosed |
| EP-0368464-A1 | Thiopene-2 carboxamide derivatives and their pharmaceutical use | LILLY S.A. (ES) | 1990-05-16 | — | — | EP | disclosed |
| US-4904686-A | 3-ALKOXYTHIOPHENE-2-CARBOXAMIDES; CENTRAL NERVOUS SYSTEM DISORDERS | LILLY INDUSTRIES LIMITED (GB) | 1990-02-27 | — | — | US | disclosed |
| US-4824958-A | Process for the preparation of n-1H-tetrazol-5-yl-2-pyrrole carboxamides | WARNER-LAMBERT COMPANY (US) | 1989-04-25 | — | — | US | disclosed |
| CN-1030916-A | Organic compound and as the application of medicine | LILLY SA (ES) | 1989-02-08 | — | — | CN | disclosed |
| EP-0297697-A1 | Thiophene-2-carboxamide derivatives and their pharmaceutical use | LILLY S.A. (ES) | 1989-01-04 | — | — | EP | disclosed |
| US-4748183-A | N-1H-tetrazol-5-yl-2-thiophene carboxamides, N-1H-tetrazol-5-yl-2-pyrrole carboxamides, N-1H-tetrazol-5-yl-2-furan carboxamides, and anti-allergic and anti-inflammatory use thereof | WARNER-LAMBERT COMPANY (US) | 1988-05-31 | — | — | US | disclosed |
| EP-0249236-A1 | N-1H-Tetrazol-5-yl-(5-Ring)-carboxamide-derivatives, a process for their manufacture, and the use thereof | WARNER-LAMBERT COMPANY (US) | 1987-12-16 | — | — | EP | disclosed |
| US-4352819-A | ANTIARRHYTHMIA AGENTS | LAEVOSAN-GESELLSCHAFT MBH & CO. KG (AT) | 1982-10-05 | — | — | US | disclosed |