Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | NAMPT | P43490 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4707395 | 0.95 | LMNA (0.75) | LMNAALDH1A1TSHRUSP2NAMPT | |
| SCHEMBL1402561 | 0.87 | TSHR (0.69) | LMNAALDH1A1TSHRUSP2NAMPT | |
| SCHEMBL3033526 | 0.82 | SMN1; SMN2 (0.66) | LMNAALDH1A1TSHRUSP2NAMPT | |
| SCHEMBL4768542 | 0.82 | KMT2A (0.69) | LMNAALDH1A1TSHRUSP2NAMPT | |
| SCHEMBL13213711 | 0.82 | SMN1; SMN2 (0.69) | LMNAALDH1A1TSHRUSP2NAMPT | |
| SCHEMBL10194836 | 0.82 | SMN1; SMN2 (0.73) | ALDH1A1TSHRUSP2NAMPTSMN1; SMN2 | |
| SCHEMBL6068990 | 0.82 | SMN1; SMN2 (0.69) | LMNAALDH1A1TSHRUSP2NAMPT | |
| SCHEMBL5474202 | 0.81 | ALDH1A1 (0.71) | LMNAALDH1A1NAMPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL15317663 | 0.80 | SMN1; SMN2 (0.70) | LMNAALDH1A1TSHRUSP2NAMPT | |
| SCHEMBL4488063 | 0.79 | NAMPT (0.63) | LMNAALDH1A1TSHRUSP2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0373891-B1 | Anti-tumour agents | ICI PLC (GB) | 1994-11-02 | — | — | EP | disclosed |
| EP-0373891-A2 | Anti-tumour agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-06-20 | — | — | EP | disclosed |