Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9366606 | 0.85 | LRRK2 (0.46) | MAOBADRA2AADRA1AMAPK1ALDH1A1 | |
| SCHEMBL9188156 | 0.84 | ADRA2A (0.51) | MAOBADRA2AADRA1AMAPK1ADRB2 | |
| SCHEMBL9367608 | 0.83 | MAOB (0.68) | MAOBMRGPRX4TSHRAPPMAPK1 | |
| SCHEMBL9577598 | 0.81 | GPBAR1 (0.58) | TSHRMAPK1ALDH1A1 | |
| SCHEMBL791569 | 0.79 | MAOB (1.00) | MAOBMRGPRX4APPBCHEABCB1 | |
| SCHEMBL22498563 | 0.79 | ADRA2A (0.51) | MAOBADRA2AADRA1AMRGPRX4ADRB2 | |
| SCHEMBL9188298 | 0.79 | ADRA2A (0.51) | MAOBADRA2AADRA1AMRGPRX4ADRB2 | |
| SCHEMBL15079885 | 0.77 | TSHR (0.57) | MAOBTSHRMAPK1ALDH1A1KDM4E | |
| Ethylene Glycol SCHEMBL29003668 | 0.76 | MAOB (0.87) | MAOBMRGPRX4APPBCHEABCB1 | |
| SCHEMBL6382820 | 0.76 | MAOB (0.53) | MAOBADRA2AADRA1AMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0391624-B1 | Substituted 1-[3-heteroarylmethoxy)phenyl] alkanols and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER (US) | 1994-04-06 | — | — | EP | disclosed |
| US-5248685-A | Substituted 1-[3-(heteroarylmethoxy)phenyl]alkanols and related compounds in the treatment of asthma | PFIZER INC. (US) | 1993-09-28 | — | — | US | disclosed |
| WO-1990012006-A1 | SUBSTITUTED 1-[3-(HETEROARYLMETHOXY)PHENYL]ALKANOLS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1990-10-18 | — | — | WO | disclosed |
| EP-0391624-A1 | Substituted 1-[3-heteroarylmethoxy)phenyl] alkanols and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1990-10-10 | — | — | EP | disclosed |