Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.72 |
| ▸ | HTR2C | P28335 | 5/20 | 0.72 |
| ▸ | HTR7 | P34969 | 4/20 | 0.72 |
| ▸ | HTR6 | P50406 | 3/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9362999 | 0.99 | HTR2A (0.71) | HTR2AHTR2CHTR7HTR6MAPT | |
| SCHEMBL10508915 | 0.89 | MAPT (0.59) | HTR2AHTR2CHTR7HTR6MAPT | |
| SCHEMBL9444495 | 0.84 | KCNH2 (0.58) | HTR2AHTR2CHTR7HTR6MAPT | |
| SCHEMBL27334030 | 0.84 | SIGMAR1 (0.56) | HTR2AGRM2KMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9444430 | 0.83 | KCNH2 (0.59) | HTR2AHTR2CHTR7HTR6MAPT | |
| SCHEMBL9500292 | 0.82 | ALDH1A1 (0.69) | HTR2AHTR2CHTR7HTR6MAPT | |
| SCHEMBL10709567 | 0.82 | HTR2A (0.53) | HTR2AHTR2CHTR7HTR6MAPT | |
| SCHEMBL1583307 | 0.82 | HTR2A (0.88) | HTR2AHTR2CHTR7HTR6GRM2 | |
| SCHEMBL9363920 | 0.81 | HTR2A (0.55) | HTR2AHTR2CHTR7HTR6MAPT | |
| SCHEMBL1582719 | 0.81 | KCNH2 (0.83) | HTR2AHTR2CHTR7HTR6CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0360275-B1 | Imidazole antiarrhythmics | MERRELL DOW PHARMA (US) | 1994-01-12 | — | — | EP | disclosed |
| EP-0360275-A2 | Imidazole antiarrhythmics | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-28 | — | — | EP | disclosed |
| US-4868194-A | Imidazole antiarrhythmics | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-19 | — | — | US | disclosed |