Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 1/20 | 0.42 |
| ▸ | TLR2 | O60603 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | HAO1 | Q9UJM8 | 5/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.38 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.38 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.38 |
| ▸ | MELK | Q14680 | 1/20 | 0.38 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9368339 | 0.81 | HAO1 (0.45) | TLR4TLR2HAO1GRM5ALDH1A1 | |
| SCHEMBL9049445 | 0.81 | TLR4 (0.47) | TLR4TLR2HAO1GRM5FFAR4 | |
| SCHEMBL9386945 | 0.81 | ALOX5 (0.59) | ALOX5HAO1ALDH1A1FFAR1LTA4H | |
| SCHEMBL9049379 | 0.80 | ALOX5 (0.73) | TLR4TLR2ALOX5HAO1GRM5 | |
| SCHEMBL9050814 | 0.80 | GRM5 (0.47) | HAO1GRM5 | |
| SCHEMBL9049679 | 0.80 | L3MBTL1 (0.49) | ALOX5HAO1ALDH1A1EGFRMAP4K4 | |
| SCHEMBL9049046 | 0.80 | EGFR (0.43) | ALOX5HAO1GRM5FFAR1EGFR | |
| SCHEMBL29612417 | 0.77 | TLR4 (0.56) | TLR4TLR2GRM5ALDH1A1FFAR4 | |
| SCHEMBL12129555 | 0.77 | TLR4 (0.56) | TLR4TLR2GRM5ALDH1A1FFAR4 | |
| SCHEMBL9046569 | 0.76 | TLR4 (0.44) | TLR4TLR2ALOX5HAO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5559144-A | LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| US-5476873-A | Inhibit biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1995-12-19 | — | — | US | disclosed |