Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | CBFB | Q13951 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9368658 | 0.87 | IDO1 (0.51) | TGFBR1NPC1KDM4EMITFGAA | |
| SCHEMBL9367732 | 0.85 | IDO1 (0.52) | TGFBR1NPC1KDM4EMITFGAA | |
| Bromide SCHEMBL9368207 | 0.81 | TGFBR1 (0.43) | TGFBR1NPC1KDM4EMITFGAA | |
| SCHEMBL7844784 | 0.80 | TGFBR1 (0.44) | TGFBR1NPC1KDM4EMITFGAA | |
| SCHEMBL12111614 | 0.76 | KDM4E (0.53) | TGFBR1NPC1KDM4EGAARAB9A | |
| SCHEMBL22650294 | 0.74 | KDM4E (0.51) | TGFBR1NPC1KDM4EGAARAB9A | |
| SCHEMBL13078802 | 0.73 | KDM4E (0.50) | TGFBR1NPC1KDM4EGAARAB9A | |
| SCHEMBL30229669 | 0.73 | NPC1 (0.59) | TGFBR1NPC1KDM4EMITFGAA | |
| SCHEMBL30427456 | 0.73 | NPC1 (0.59) | TGFBR1NPC1KDM4EMITFGAA | |
| SCHEMBL39129 | 0.73 | NPC1 (0.59) | TGFBR1NPC1KDM4EMITFGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625151-A1 | THIAZOLYL-PYRIDINE DERIVATIVES AND THEIR USE AS GASTRIC ACID SECRETION INHIBITORS | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1994-11-23 | — | — | EP | claimed |
| WO-1993015071-A1 | THIAZOLYL-PYRIDINE DERIVATIVES AND THEIR USE AS GASTRIC ACID SECRETION INHIBITORS | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1993-08-05 | — | — | WO | claimed |
| EP-0625151-A1 | THIAZOLYL-PYRIDINE DERIVATIVES AND THEIR USE AS GASTRIC ACID SECRETION INHIBITORS | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015071-A1 | THIAZOLYL-PYRIDINE DERIVATIVES AND THEIR USE AS GASTRIC ACID SECRETION INHIBITORS | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1993-08-05 | — | — | WO | disclosed |