Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9367732 | 0.99 | IDO1 (0.52) | IDO1DCTPP1TGFBR1NPC1KDM4E | |
| Bromide SCHEMBL9368482 | 0.87 | TGFBR1 (0.49) | IDO1DCTPP1TGFBR1NPC1KDM4E | |
| Bromide SCHEMBL9368207 | 0.80 | TGFBR1 (0.43) | IDO1DCTPP1TGFBR1NPC1KDM4E | |
| SCHEMBL7844784 | 0.79 | TGFBR1 (0.44) | DCTPP1TGFBR1NPC1KDM4ERAB9A | |
| SCHEMBL39129 | 0.72 | NPC1 (0.59) | IDO1DCTPP1TGFBR1NPC1KDM4E | |
| SCHEMBL30229669 | 0.72 | NPC1 (0.59) | IDO1DCTPP1TGFBR1NPC1KDM4E | |
| SCHEMBL30427456 | 0.72 | NPC1 (0.59) | IDO1DCTPP1TGFBR1NPC1KDM4E | |
| SCHEMBL11453550 | 0.71 | PTGS2 (0.54) | KDM4EGAAL3MBTL1MAPT | |
| SCHEMBL3714209 | 0.70 | NPC1 (0.57) | IDO1DCTPP1TGFBR1NPC1KDM4E | |
| SCHEMBL21742496 | 0.69 | NPC1 (0.56) | DCTPP1TGFBR1NPC1KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625151-A1 | THIAZOLYL-PYRIDINE DERIVATIVES AND THEIR USE AS GASTRIC ACID SECRETION INHIBITORS | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015071-A1 | THIAZOLYL-PYRIDINE DERIVATIVES AND THEIR USE AS GASTRIC ACID SECRETION INHIBITORS | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1993-08-05 | — | — | WO | disclosed |