Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.56 |
| ▸ | GBA1 | P04062 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.39 |
| ▸ | GBA2 | Q9HCG7 | 6/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9869264 | 0.98 | BRD4 (0.54) | BRD4GBA1L3MBTL1MEN1CYP2C19 | |
| SCHEMBL28499610 | 0.98 | BRD4 (0.54) | BRD4GBA1L3MBTL1MEN1CYP2C19 | |
| SCHEMBL11623610 | 0.95 | BRD4 (0.58) | BRD4GBA1L3MBTL1MEN1CYP2C19 | |
| SCHEMBL9368747 | 0.83 | GBA1 (0.42) | BRD4GBA1L3MBTL1MEN1CYP2C19 | |
| SCHEMBL3745079 | 0.77 | CHRM2 (0.45) | GBA1L3MBTL1MEN1CYP2C19KMT2A | |
| SCHEMBL25101221 | 0.77 | BRD4 (0.56) | BRD4GBA1L3MBTL1CYP2C19KMT2A | |
| SCHEMBL28497027 | 0.76 | GBA1 (0.47) | GBA1L3MBTL1MEN1CYP2C19KMT2A | |
| SCHEMBL8292876 | 0.75 | POLB (0.58) | GBA1L3MBTL1MEN1CYP2C19KMT2A | |
| SCHEMBL8084223 | 0.74 | POLB (0.56) | GBA1L3MBTL1MEN1CYP2C19KMT2A | |
| SCHEMBL14477954 | 0.74 | POLB (0.56) | GBA1L3MBTL1MEN1CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589971-A1 | COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-06 | — | — | EP | disclosed |
| WO-1992022527-A2 | 3-SUBSTITUTED PYRROLIDINE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1992-12-23 | — | — | WO | disclosed |