Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | PTPRB | P23467 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847350 | 0.86 | HCAR2 (0.47) | CHRM1ALDH1A1LMNAHCAR2SMN1; SMN2 | |
| SCHEMBL6643069 | 0.85 | POLB (0.43) | CYP19A1NAMPTPTPRBALDH1A1LMNA | |
| SCHEMBL16625742 | 0.82 | CHRM5 (0.40) | CHRM5CHRM1CYP19A1NAMPTALDH1A1 | |
| SCHEMBL23841133 | 0.80 | CYP19A1 (0.43) | CHRM5CHRM1CYP19A1NAMPTALDH1A1 | |
| SCHEMBL10712569 | 0.78 | LMNA (0.55) | FFAR1ALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL6643065 | 0.76 | NAMPT (0.46) | CYP19A1NAMPTPTPRBALDH1A1KMT2A | |
| SCHEMBL9366627 | 0.76 | CA12 (0.49) | CHRM5CHRM1ALDH1A1MEN1LMNA | |
| SCHEMBL10713530 | 0.76 | CHRNA7 (0.56) | — | |
| SCHEMBL9518676 | 0.74 | CYP19A1 (0.46) | CHRM5CHRM1CYP19A1NAMPTALDH1A1 | |
| SCHEMBL6131620 | 0.73 | KMT2A (0.45) | CHRM1PTPRBALDH1A1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0583421-A1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1994-02-23 | — | — | EP | disclosed |