Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.56 |
| ▸ | TBXAS1 | P24557 | 7/20 | 0.50 |
| ▸ | FKBP1A | P62942 | 7/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.48 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10712569 | 0.85 | LMNA (0.55) | FKBP1ATDP1 | |
| SCHEMBL774152 | 0.85 | FKBP1A (0.60) | CHRNA7TBXAS1FKBP1AMTORFKBP4 | |
| SCHEMBL8741860 | 0.80 | LMNA (0.58) | FKBP1ATDP1 | |
| SCHEMBL2954088 | 0.78 | CHRNA7 (0.63) | CHRNA7TBXAS1FKBP1AL3MBTL1TDP1 | |
| SCHEMBL14168872 | 0.78 | CHRNA7 (0.53) | CHRNA7TBXAS1FKBP1AMTORFKBP4 | |
| SCHEMBL7057410 | 0.77 | ALDH1A1 (0.48) | TDP1 | |
| SCHEMBL7847350 | 0.77 | HCAR2 (0.47) | L3MBTL1TDP1 | |
| SCHEMBL774482 | 0.76 | RIPK1 (0.54) | CHRNA7TBXAS1FKBP1AMTORFKBP4 | |
| SCHEMBL10713534 | 0.76 | CHRNA7 (0.54) | CHRNA7TBXAS1FKBP1AMTORFKBP4 | |
| Butane SCHEMBL10713527 | 0.76 | CHRNA7 (0.60) | CHRNA7TBXAS1FKBP1AL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0173041-B1 | 2-SUBSTITUTED-1,3-PROPYLIDENEDIPHOSPHONATE DERIVATIVES, THE PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1988-11-30 | — | — | EP | disclosed |
| US-4696920-A | CARDIOVASCULAR DISORDERS | SYMPHAR S.A. (CH) | 1987-09-29 | — | — | US | disclosed |
| EP-0173041-A1 | 2-Substituted-1,3-propylidenediphosphonate derivatives, the process for their preparation and pharmaceutical compositions containing them | SYMPHAR S.A. (CH) | 1986-03-05 | — | — | EP | disclosed |