Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9370175 | 0.85 | HRH4 (0.50) | HRH4SYKAKR1C3RAB9ANPC1 | |
| SCHEMBL9369912 | 0.83 | HRH4 (0.53) | HRH4SYKMEN1KMT2ADRD2 | |
| SCHEMBL8794793 | 0.81 | HRH4 (0.46) | HRH4SYKAKR1C3RAB9ANPC1 | |
| SCHEMBL8794398 | 0.81 | ADRA2A (0.51) | HRH4SYKAKR1C3RAB9ANPC1 | |
| SCHEMBL9370616 | 0.72 | HRH4 (0.55) | HRH4SYKMEN1KMT2ADRD2 | |
| SCHEMBL8792157 | 0.71 | NMT1 (0.35) | DRD2DRD3 | |
| SCHEMBL9370906 | 0.70 | HRH4 (0.56) | HRH4SYKMEN1KMT2ADRD2 | |
| SCHEMBL8794312 | 0.70 | HRH4 (0.49) | HRH4SYKAKR1C3RAB9ANPC1 | |
| SCHEMBL9370464 | 0.69 | ADRA2A (0.68) | SYK | |
| SCHEMBL8794886 | 0.69 | ADRA2A (0.55) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0594702-A1 | SUBSTITUTED INDOLES AS ANTI-AIDS PHARMACEUTICALS. | UPJOHN CO (US) | 1994-05-04 | — | — | EP | disclosed |