Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | MDH1 | P40925 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9369912 | 0.87 | HRH4 (0.53) | HRH4OPRM1ADRA2AADORA3CHRM1 | |
| SCHEMBL9370464 | 0.83 | ADRA2A (0.68) | OPRM1ADRA2AADORA3CHRM1MAOA | |
| SCHEMBL8795199 | 0.80 | HRH4 (0.55) | HRH4OPRM1ADRA2AADORA3CHRM1 | |
| SCHEMBL12423824 | 0.79 | OPRM1 (0.70) | HRH4OPRM1ADRA2AADORA3CHRM1 | |
| SCHEMBL6130883 | 0.73 | HRH4 (1.00) | HRH4OPRM1HRH3 | |
| SCHEMBL8796610 | 0.73 | ADRA2A (0.63) | HRH4OPRM1ADRA2AADORA3CHRM1 | |
| SCHEMBL2818013 | 0.71 | ADRA2A (0.58) | HRH4OPRM1ADRA2AADORA3CHRM1 | |
| SCHEMBL9370598 | 0.70 | HRH4 (0.47) | HRH4DRD3MEN1KMT2ADRD2 | |
| SCHEMBL17938735 | 0.70 | HRH4 (0.76) | HRH4OPRM1DRD3ABCB1HRH3 | |
| SCHEMBL14247275 | 0.70 | KMT2A (0.71) | HRH4DRD3MEN1KMT2AABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0594702-A1 | SUBSTITUTED INDOLES AS ANTI-AIDS PHARMACEUTICALS. | UPJOHN CO (US) | 1994-05-04 | — | — | EP | disclosed |