Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9375543 | 0.88 | AXL (0.36) | HTTKDM4EMAPTTSHR | |
| SCHEMBL9372394 | 0.88 | KDM4E (0.31) | KDM4E | |
| SCHEMBL8538103 | 0.81 | HTR2C (0.39) | AKR1C3AKR1C2LIPGKDM4EBRD4 | |
| SCHEMBL9374984 | 0.79 | TNKS (0.35) | KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL8539254 | 0.72 | KDM4E (0.35) | KDM4EBRD4MAPTLMNA | |
| SCHEMBL8545213 | 0.71 | CYP1A2 (0.42) | KDM4EBRD4MAPTCYP1A2CYP3A4 | |
| SCHEMBL8540727 | 0.70 | HTR2C (0.40) | HTTKDM4EMAPTCYP1A2CYP3A4 | |
| SCHEMBL27368420 | 0.70 | KDM4E (0.39) | LIPGKDM4ERXFP1NPC1RAB9A | |
| SCHEMBL8541594 | 0.69 | KDM4E (0.44) | KDM4EL3MBTL1MAPTKMT2AMEN1 | |
| SCHEMBL9358984 | 0.69 | KDM4E (0.41) | AKR1C3AKR1C2KDM4EL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623112-A1 | 4-ARYL-3-(HETEROARYLUREIDO)-1,2-DIHYDRO-2-OXO-QUINOLINE DERIVATIVES AS ANTIHYPERCHOLESTEROLEMIC AND ANTIATHEROSCLEROTIC AGENTS | PFIZER INC. (US) | 1994-11-09 | — | — | EP | disclosed |