Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | WEE1 | P30291 | 2/20 | 0.39 |
| ▸ | RORA | P35398 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | RORB | Q92753 | 1/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544707 | 0.86 | KMT2A (0.47) | KDM4EMEN1KMT2ACHEK1WEE1 | |
| SCHEMBL9358921 | 0.86 | POLB (0.53) | KDM4EL3MBTL1MEN1KMT2ANPC1 | |
| SCHEMBL8541594 | 0.83 | KDM4E (0.44) | KDM4EL3MBTL1MEN1KMT2ACHEK1 | |
| SCHEMBL9358757 | 0.82 | EDNRB (0.42) | KDM4EMEN1KMT2ACHEK1WEE1 | |
| SCHEMBL9358730 | 0.81 | LMNA (0.44) | L3MBTL1MEN1KMT2AWEE1RORC | |
| SCHEMBL6636719 | 0.76 | ROCK2 (0.43) | L3MBTL1MEN1KMT2AWEE1MAP3K5 | |
| SCHEMBL9363440 | 0.76 | KMT2A (0.46) | KDM4EMEN1KMT2A | |
| SCHEMBL27337810 | 0.75 | KMT2A (0.46) | KDM4EMEN1KMT2A | |
| SCHEMBL27396929 | 0.74 | EGFR (0.54) | KDM4EL3MBTL1MEN1KMT2AMAP3K5 | |
| SCHEMBL9359029 | 0.74 | RECQL (0.45) | KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421456-B1 | Quinoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-12-28 | — | — | EP | disclosed |
| US-5223513-A | Anticholesterol agent | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-06-29 | — | — | US | disclosed |
| EP-0421456-A2 | Quinoline derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-04-10 | — | — | EP | disclosed |