Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 5/20 | 0.71 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.71 |
| ▸ | MMP2 | P08253 | 1/20 | 0.67 |
| ▸ | MMP8 | P22894 | 1/20 | 0.67 |
| ▸ | FAAH | O00519 | 1/20 | 0.65 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | CNR2 | P34972 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9370910 | 0.89 | ROCK1 (0.68) | ROCK1ROCK2MMP2MMP8FAAH | |
| SCHEMBL9376980 | 0.89 | ROCK1 (0.68) | ROCK1ROCK2MMP2MMP8FAAH | |
| SCHEMBL9376900 | 0.89 | ROCK1 (0.71) | ROCK1ROCK2MMP2MMP8FAAH | |
| SCHEMBL9376473 | 0.88 | ROCK1 (0.60) | ROCK1ROCK2MMP2MMP8FAAH | |
| SCHEMBL9371002 | 0.87 | MMP2 (0.61) | ROCK1ROCK2MMP2MMP8FAAH | |
| SCHEMBL9370676 | 0.87 | ROCK1 (0.64) | ROCK1ROCK2MMP2MMP8LMNA | |
| SCHEMBL9371125 | 0.86 | ROCK1 (0.63) | ROCK1ROCK2MMP2MMP8FAAH | |
| SCHEMBL9371187 | 0.84 | FAAH (0.56) | ROCK1ROCK2MMP2MMP8FAAH | |
| SCHEMBL2560351 | 0.83 | ROCK1 (1.00) | ROCK1ROCK2MMP2MMP8FAAH | |
| SCHEMBL9370963 | 0.83 | ROCK1 (0.61) | ROCK1ROCK2MMP2MMP8FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589985-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1994-04-06 | — | — | EP | disclosed |
| WO-1993000342-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1993-01-07 | — | — | WO | disclosed |
| EP-0519449-A1 | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-23 | — | — | EP | disclosed |