Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 10/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BCAT2 | O15382 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2808132 | 0.84 | GPR35 (0.52) | GPR35PKMNPSR1RXFP1HPGD | |
| Hydrochloric Acid SCHEMBL11597163 | 0.81 | GPR35 (0.50) | GPR35PKMNPSR1RXFP1HPGD | |
| SCHEMBL731095 | 0.81 | GPR35 (0.50) | GPR35PKMNPSR1RXFP1HPGD | |
| SCHEMBL10928844 | 0.79 | ALDH1A1 (0.53) | NPSR1HPGDALDH1A1LMNAKDM4E | |
| SCHEMBL28361289 | 0.75 | GPR35 (0.48) | GPR35PKMNPSR1RXFP1HPGD | |
| SCHEMBL10487795 | 0.73 | ELANE (0.42) | GPR35 | |
| SCHEMBL16311870 | 0.72 | GPR35 (0.50) | GPR35PKMNPSR1RXFP1HPGD | |
| SCHEMBL1760864 | 0.71 | GPR35 (0.55) | GPR35PKMNPSR1RXFP1HPGD | |
| SCHEMBL2727696 | 0.71 | GPR35 (0.66) | GPR35PKMNPSR1RXFP1HPGD | |
| SCHEMBL15342922 | 0.70 | GPR35 (0.67) | GPR35PKMNPSR1RXFP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0368464-B1 | Thiopene-2 carboxamide derivatives and their pharmaceutical use | LILLY SA (ES) | 1994-02-02 | — | — | EP | disclosed |
| US-5021449-A | N-pyrrolidinyl-3 alkyloxythienyl-2-carboxamides; antiemetics, antidepressants, schizophrenia | LILLY S.A. (ES) | 1991-06-04 | — | — | US | disclosed |
| EP-0368464-A1 | Thiopene-2 carboxamide derivatives and their pharmaceutical use | LILLY S.A. (ES) | 1990-05-16 | — | — | EP | disclosed |
| US-4914123-A | Acyloxythiophene derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1990-04-03 | — | — | US | disclosed |