Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.47 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | RORA | P35398 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | RORB | Q92753 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30224224 | 0.78 | HDAC1 (0.49) | HDAC1HDAC6HDAC8KMT2ARORA | |
| SCHEMBL23993198 | 0.78 | HDAC1 (0.49) | HDAC1HDAC6HDAC8KMT2ARORA | |
| SCHEMBL9372755 | 0.77 | RORA (0.34) | BRPF1HDAC1HDAC6HDAC8KMT2A | |
| SCHEMBL29757375 | 0.76 | CA12 (0.57) | CA12BRD4BRPF1CA9KAT2B | |
| SCHEMBL3287841 | 0.76 | CA12 (0.52) | CA12BRD4BRPF1CA9KAT2B | |
| SCHEMBL11664547 | 0.76 | CA12 (0.52) | CA12BRD4BRPF1CA9KAT2B | |
| SCHEMBL3441071 | 0.76 | CA12 (0.57) | CA12BRD4BRPF1CA9KAT2B | |
| SCHEMBL31251898 | 0.76 | CA12 (0.52) | CA12BRD4BRPF1CA9KAT2B | |
| SCHEMBL11868257 | 0.75 | HDAC1 (0.37) | HDAC1HDAC6HDAC8RORARORC | |
| SCHEMBL31016081 | 0.74 | HDAC1 (0.61) | CA12CA9HDAC1HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420511-B1 | Heterocyclic derivatives | ICI PLC (GB) | 1994-08-17 | — | — | EP | disclosed |
| US-5302594-A | Antiinflammatory agents; antiallergenic agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-04-12 | — | — | US | disclosed |
| US-5221677-A | For treating diseases mediated by leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-22 | — | — | US | disclosed |
| EP-0420511-A2 | Heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-04-03 | — | — | EP | disclosed |