Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | CCR9 | P51686 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CBX7 | O95931 | 1/20 | 0.32 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.32 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.32 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30224224 | 1.00 | HDAC1 (0.49) | HDAC1HDAC6HDAC8CCR9HTR7 | |
| SCHEMBL23621224 | 0.79 | BTK (0.37) | HDAC1HDAC6HDAC8CHEK1BTK | |
| SCHEMBL30355117 | 0.78 | BTK (0.46) | HDAC1HDAC6HDAC8CCR9HTR7 | |
| SCHEMBL9372428 | 0.78 | CA12 (0.47) | HDAC1HDAC6HDAC8KMT2ATDP1 | |
| SCHEMBL9372755 | 0.73 | RORA (0.34) | HDAC1HDAC6HDAC8CHEK1KMT2A | |
| SCHEMBL3409318 | 0.73 | HDAC1 (0.40) | HDAC1HDAC6HDAC8CCR9HTR7 | |
| SCHEMBL25005554 | 0.73 | KCNJ6 (0.34) | HDAC1HDAC6HDAC8CHEK1BTK | |
| SCHEMBL3410183 | 0.72 | KMO (0.56) | HDAC1HDAC6HDAC8CCR9NAMPT | |
| SCHEMBL31701806 | 0.72 | AKT2 (0.42) | KMT2AMEN1 | |
| SCHEMBL25865285 | 0.72 | CBX7 (0.49) | KMOKMT2ACBX7CDYL2CDYL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115698009-A | CD73 inhibiting 2,4-dioxopyrimidine compounds | 吉利德科学公司 | 2023-02-03 | — | — | CN | disclosed |
| WO-2021222522-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |