Lysine

Lysine

SCHEMBL93725

NCCCC[C@H](N)C(=O)O.O=CCC=O

nearest known ligand 0.77

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSR P00390 2/20 0.77
ARG2 P78540 4/20 0.48
ARG1 P05089 3/20 0.48
RNPEP Q9H4A4 1/20 0.47
NOS2 P35228 5/20 0.43
NOS1 P29475 3/20 0.43
CYP1A2 P05177 3/20 0.43
NOS3 P29474 2/20 0.43
TSHR P16473 2/20 0.43
CYP3A4 P08684 1/20 0.43
CPB2 Q96IY4 2/20 0.43
GLA P06280 1/20 0.43
NFKB1 P19838 1/20 0.43
APEX1 P27695 1/20 0.43
CYP2C19 P33261 1/20 0.43
BLM P54132 1/20 0.42
GRM8 O00222 1/20 0.42
GRM6 O15303 1/20 0.42
GRIN2D O15399 1/20 0.42
GRIN3B O60391 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lysine SCHEMBL27588170 1.00 GSR (0.77) GSRARG2ARG1RNPEPNOS2
Lysine SCHEMBL28046911 0.90 GSR (0.95) GSRARG2ARG1RNPEPNOS2
Lysine SCHEMBL28331087 0.89 GSR (0.77) GSRARG2ARG1RNPEPNOS2
Lysine SCHEMBL445453 0.88 GSR (0.83) GSRARG2ARG1RNPEPNOS2
Lysine SCHEMBL17102268 0.88 GSR (0.83) GSRARG2ARG1RNPEPNOS2
Lysine SCHEMBL22534312 0.88 GSR (0.83) GSRARG2ARG1RNPEPNOS2
Lysine SCHEMBL8562830 0.88 GSR (0.83) GSRARG2ARG1RNPEPNOS2
Lysine SCHEMBL2324976 0.88 GSR (0.83) GSRARG2ARG1RNPEPNOS2
Lysine SCHEMBL28214073 0.88 GSR (0.91) GSRARG2ARG1RNPEPNOS2
Lysine SCHEMBL7343 0.88 GSR (1.00) GSRARG2ARG1RNPEPNOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 173 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3617229-B1 DETECTION REAGENT AND KIT FOR IDENTIFYING ACIDIC STATE AND GLYCATION STATE OF LOW DENSITY LIPOPROTEIN YAMADA KEN ICHI (JP) 2024-03-13 EP claimed
US-11725002-B2 Detection reagents and kit for identifying oxidized state and glycated state of low-density lipoproteins YAMADA, Ken-ichi (JP) 2023-08-15 US claimed
US-20200140426-A1 DETECTION REAGENTS AND KIT FOR IDENTIFYING OXIDIZED STATE AND GLYCATED STATE OF LOW-DENSITY LIPOPROTEINS YAMADA, Ken-ichi (JP) 2020-05-07 US claimed
EP-3617229-A1 DETECTION REAGENT AND KIT FOR IDENTIFYING ACIDIC STATE AND GLYCATION STATE OF LOW DENSITY LIPOPROTEIN Yamada, Ken-Ichi (JP) 2020-03-04 EP claimed
CN-110799533-A Detection reagent and kit for identifying acidic state and glycated state of low-density lipoprotein 扶桑药品工业株式会社 2020-02-14 CN claimed
US-20050042221-A1 Compositions and methods for diagnosing Alzheimer's disease CHOJKIEN MARIO (US) 2005-02-24 US claimed
US-6811988-B2 AMYLOID PROTEIN FOR USE IN TREATMENT OF NERVOUS SYSTEM DISORDERS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2004-11-02 US claimed
EP-1339743-A2 COMPOSITIONS AND METHODS FOR DIAGNOSING ALZHEIMER'S DISEASE Chojkier, Mario (US) 2003-09-03 EP claimed
US-20030104488-A1 Compositions and methods for diagnosing Alzheimer's disease NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2003-06-05 US claimed
US-20020137112-A1 Compositions and methods for diagnosing alzheimer's disease NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2002-09-26 US claimed
WO-2002046222-A2 COMPOSITIONS AND METHODS FOR DIAGNOSING ALZHEIMER'S DISEASE CHOJKIER MARIO (US) 2002-06-13 WO claimed
WO-2024117698-A1 FOOD AND PHARMACEUTICAL COMPOSITION FOR DETOXIFYING ENDOGENOUS ALDEHYDES PICOENTECH Co., LTD. (KR) 2024-06-06 WO disclosed
US-20240182915-A1 FOOD AND PHARMACEUTICAL COMPOSITION FOR DETOXIFYING ENDOGENOUS ALDEHYDES PICOENTECH Co., LTD. (KR) 2024-06-06 US disclosed
US-20240180985-A1 FOOD AND PHARMACEUTICAL COMPOSITION FOR TREATMENT OF FATTY LIVER AND INFLAMMATION BY RELIEVING ENDOPLASMIC RETICULUM STRESS PICOENTECH Co., LTD. (KR) 2024-06-06 US disclosed
WO-2024117697-A1 FOOD AND PHARMACEUTICAL COMPOSITION FOR TREATMENT OF FATTY LIVER AND INFLAMMATION BY RELIEVING ENDOPLASMIC RETICULUM STRESS PICOENTECH Co., LTD. (KR) 2024-06-06 WO disclosed
US-5922757-A ADMINISTERING ALPHA-TOCOPHEROL TO PATIENTS WITH HEPATITIS C WHO ARE REFRACTORY TO INTERFERON THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1999-07-13 US disclosed
WO-1998014181-A1 TREATMENT AND PREVENTION OF HEPATIC DISORDERS REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1998-04-09 WO disclosed
WO-1997026913-A1 A POLYPEPTIDE FROM LUNG EXTRACT WHICH BINDS AMYLOID-β PEPTIDE THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 1997-07-31 WO disclosed
EP-0784681-A1 METHOD OF USING A SCAVENGER RECEPTOR IN THE TREATMENT OF ATHEROSCLEROSIS WARNER-LAMBERT COMPANY (US) 1997-07-23 EP disclosed
WO-1996011268-A1 METHOD OF USING A SCAVENGER RECEPTOR IN THE TREATMENT OF ATHEROSCLEROSIS WARNER-LAMBERT COMPANY (US) 1996-04-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11725002-B2 Detection reagents and kit for identifying oxidized state and glycated state of low-density lipoproteins APOL1, LDLR, LOX GSR 356/4885ARG2 1350/4885ARG1 2901/4885
US-20200140426-A1 DETECTION REAGENTS AND KIT FOR IDENTIFYING OXIDIZED STATE AND GLYCATED STATE OF LOW-DENSITY LIPOPROTEINS APOL1, LDLR, LOX GSR 356/4885ARG2 1350/4885ARG1 2901/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.