Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | TP53 | P04637 | 1/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.97 |
| ▸ | TSHR | P16473 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.97 |
| ▸ | CCR3 | P51677 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL866873 | 0.98 | SIGMAR1 (1.00) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL9521523 | 0.94 | SIGMAR1 (1.00) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL8099058 | 0.90 | SIGMAR1 (0.82) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL7402940 | 0.88 | SIGMAR1 (0.81) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL7372250 | 0.88 | SIGMAR1 (0.81) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL29048480 | 0.88 | SIGMAR1 (0.81) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL29048471 | 0.88 | SIGMAR1 (0.81) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| Fumaric Acid SCHEMBL1604005 | 0.88 | SIGMAR1 (0.80) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| Maleic Acid SCHEMBL1604001 | 0.88 | SIGMAR1 (0.80) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL9374358 | 0.87 | SIGMAR1 (0.81) | SIGMAR1MEN1TP53CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | claimed |
| EP-0507863-A4 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | — | 1993-07-07 | — | — | EP | claimed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | claimed |
| EP-0507863-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1992-10-14 | — | — | EP | claimed |
| WO-1991009594-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1991-07-11 | — | — | WO | claimed |
| EP-0591333-A1 | AZANORBORNANE DERIVATIVES. | PFIZER (US) | 1994-04-13 | — | — | EP | disclosed |