Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.80 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.80 |
| ▸ | S1PR1 known ✓ | P21453 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.80 |
| ▸ | TP53 | P04637 | 1/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.80 |
| ▸ | TSHR | P16473 | 1/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.80 |
| ▸ | CCR3 | P51677 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL1604001 | 1.00 | SIGMAR1 (0.80) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL866873 | 0.89 | SIGMAR1 (1.00) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL9373391 | 0.88 | SIGMAR1 (1.00) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL9521523 | 0.85 | SIGMAR1 (1.00) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL7402940 | 0.83 | SIGMAR1 (0.81) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| Maleic Acid SCHEMBL19359022 | 0.82 | SIGMAR1 (0.74) | SIGMAR1CCR3 | |
| SCHEMBL7372250 | 0.80 | SIGMAR1 (0.81) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL29048471 | 0.80 | SIGMAR1 (0.81) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL29048480 | 0.80 | SIGMAR1 (0.81) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL8099058 | 0.79 | SIGMAR1 (0.82) | SIGMAR1MEN1TP53CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110152284-A1 | Sigma ligands for neuronal regeneration and functional recovery | WIELOCH TADEUSZ | 2011-06-23 | — | — | US | disclosed |
| US-20110082154-A1 | Sigma ligands for neuronal regeneration and functional recovery | OKSENBERG DONNA | 2011-04-07 | — | — | US | disclosed |
| US-7863272-B2 | Sigma ligands for neuronal regeneration and functional recovery | M'S SCIENCE CORPORATION (JP) | 2011-01-04 | — | — | US | disclosed |
| US-7829562-B2 | Sigma ligands for neuronal regeneration and functional recovery | M'S SCIENCE CORPORATION (JP) | 2010-11-09 | — | — | US | disclosed |
| EP-1951241-A2 | SIGMA LIGANDS FOR NEURONAL REGENERATION AND FUNCTIONAL RECOVERY | M's Science Corporation (JP) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007053580-A2 | SIGMA LIGANDS FOR NEURONAL REGENERATION AND FUNCTIONAL RECOVERY | M'S SCIENCE CORPORATION (JP) | 2007-05-10 | — | — | WO | disclosed |
| US-20060052386-A1 | Sigma ligands for neuronal regeneration and functional recovery | M'S SCIENCE CORPORATION (JP) | 2006-03-09 | — | — | US | disclosed |
| US-20060014753-A1 | Sigma ligands for neuronal regeneration and functional recovery | M'S SCIENCE CORPORATION (JP) | 2006-01-19 | — | — | US | disclosed |
| US-20050059689-A1 | Sigma ligands for neuronal regeneration and functional recovery | M'S SCIENCE CORPORATION (JP) | 2005-03-17 | — | — | US | disclosed |
| US-20050032827-A1 | Sigma ligands for neuronal regeneration and functional recovery | M'S SCIENCE CORPORATION (JP) | 2005-02-10 | — | — | US | disclosed |
| US-20050020483-A1 | Sigma ligands for neuronal regeneration and functional recovery | M'S SCIENCE CORPORATION (JP) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152284-A1 | Sigma ligands for neuronal regeneration and functional recovery | SIGMAR1, TMEM97, LPAR6 | MEN1 4836/4885KMT2A 4433/4885S1PR1 166/4885 |
| US-20110082154-A1 | Sigma ligands for neuronal regeneration and functional recovery | SIGMAR1, TMEM97, GAP43 | MEN1 4828/4885KMT2A 4531/4885S1PR1 86/4885 |
| US-20050020483-A1 | Sigma ligands for neuronal regeneration and functional recovery | SIGMAR1, TMEM97, OPRL1 | MEN1 4711/4885KMT2A 4382/4885S1PR1 56/4885 |
| US-20060014753-A1 | Sigma ligands for neuronal regeneration and functional recovery | SIGMAR1, GAP43, TMEM97 | MEN1 4806/4885KMT2A 4253/4885S1PR1 106/4885 |
| US-20050059689-A1 | Sigma ligands for neuronal regeneration and functional recovery | SIGMAR1, TMEM97, GAP43 | MEN1 4836/4885KMT2A 4517/4885S1PR1 77/4885 |
| US-20060052386-A1 | Sigma ligands for neuronal regeneration and functional recovery | SIGMAR1, OGFR, OPRK1 | MEN1 4816/4885KMT2A 4511/4885S1PR1 116/4885 |
| US-20050032827-A1 | Sigma ligands for neuronal regeneration and functional recovery | SIGMAR1, TMEM97, MSR1 | MEN1 3860/4885KMT2A 4390/4885S1PR1 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.