Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.46 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31402270 | 0.77 | CCR2 (0.59) | CCR2PPARGAGTR1AGTR2PLA2G10 | |
| SCHEMBL4802191 | 0.77 | CCR2 (0.59) | CCR2PPARGAGTR1AGTR2PLA2G10 | |
| SCHEMBL7151151 | 0.77 | CCR2 (0.52) | CCR2PPARGAGTR1AGTR2LMNA | |
| SCHEMBL30665831 | 0.76 | DAO (0.36) | CCR2ALDH1A1 | |
| SCHEMBL7554153 | 0.75 | CCR2 (0.57) | CCR2PPARGAGTR1AGTR2HDAC1 | |
| SCHEMBL1868317 | 0.75 | LMNA (0.56) | CCR2TP53LMNAKDM4EALDH1A1 | |
| SCHEMBL11033122 | 0.74 | CCR2 (0.56) | CCR2PPARGAGTR1AGTR2PLA2G10 | |
| SCHEMBL15151075 | 0.74 | CCR2 (0.56) | CCR2PPARGAGTR1AGTR2PLA2G10 | |
| SCHEMBL5624852 | 0.74 | CCR2 (0.77) | CCR2PPARGPLA2G10 | |
| SCHEMBL5378162 | 0.73 | CCR2 (1.00) | CCR2PLA2G10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0377450-B1 | Substituted indole, benzofuran and benzothiophene derivatives as 5-lipoxygenase inhibitors | DU PONT MERCK PHARMA (US) | 1994-07-27 | — | — | EP | disclosed |
| US-5093351-A | Antiinflammatory agents | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-03-03 | — | — | US | disclosed |
| EP-0377450-A1 | Substituted indole, benzofuran and benzothiophene derivatives as 5-lipoxygenase inhibitors | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-07-11 | — | — | EP | disclosed |