Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9589002 | 0.77 | HPGD (0.46) | GAAPOLBALDH1A1HPGDKDM4E | |
| SCHEMBL9375075 | 0.73 | KDM4E (0.58) | GAAALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL2417850 | 0.72 | SIRT1 (0.67) | POLBALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL13995853 | 0.70 | GAA (0.71) | GAANPC1POLBALDH1A1HPGD | |
| SCHEMBL6029149 | 0.69 | TDP1 (0.43) | GAAPOLBALDH1A1HPGDKDM4E | |
| SCHEMBL7207144 | 0.68 | HPGD (0.50) | ALDH1A1HPGDMAPTSIRT1L3MBTL1 | |
| SCHEMBL9587719 | 0.68 | TYMS (0.35) | GAAPOLBALDH1A1HPGDKDM4E | |
| SCHEMBL11705929 | 0.68 | PDE7A (0.48) | ALDH1A1HPGDMAPTSIRT1L3MBTL1 | |
| SCHEMBL19319667 | 0.68 | SIRT1 (0.47) | POLBALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL9475977 | 0.67 | KDM4E (0.67) | GAANPC1POLBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0607217-A1 | PYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-27 | — | — | EP | disclosed |
| WO-1993007137-A1 | PYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1993-04-15 | — | — | WO | disclosed |