Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | AKT1 | P31749 | 1/20 | 0.55 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5014224 | 0.85 | RECQL (0.83) | RECQLALDH1A1SMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL5009469 | 0.84 | RECQL (0.81) | RECQLALDH1A1SMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL9197789 | 0.84 | RECQL (0.81) | RECQLALDH1A1SMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL8128443 | 0.82 | MAPT (0.68) | KMT2AMAPT | |
| SCHEMBL15597475 | 0.80 | SMN1; SMN2 (1.00) | RECQLALDH1A1SMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL13720543 | 0.79 | SMN1; SMN2 (0.74) | RECQLALDH1A1SMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL9200706 | 0.77 | AKR1B1 (0.73) | RECQLALDH1A1SMN1; SMN2L3MBTL1CYP1A2 | |
| SCHEMBL27505080 | 0.77 | RECQL (0.44) | RECQLALDH1A1SMN1; SMN2L3MBTL1CYP1A2 | |
| SCHEMBL24076900 | 0.76 | CYP1A2 (0.77) | RECQLALDH1A1SMN1; SMN2L3MBTL1CYP1A2 | |
| SCHEMBL5060770 | 0.76 | RECQL (0.67) | RECQLALDH1A1SMN1; SMN2MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397350-B1 | Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof | PFIZER (US) | 1994-04-06 | — | — | EP | disclosed |
| EP-0295051-B1 | PREPARATION OF OXOPHTHALAZINYL ACETIC ACIDS HAVING BENZOTHIAZOLE OR OTHER HETEROCYCLIC SIDE CHAINS | PFIZER INC. (US) | 1993-06-09 | — | — | EP | disclosed |
| US-5182391-A | Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof | PFIZER INC. (US) | 1993-01-26 | — | — | US | disclosed |
| US-5171862-A | Process and indazole intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof | PFIZER INC. (US) | 1992-12-15 | — | — | US | disclosed |
| US-5075442-A | Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof | PFIZER INC. (US) | 1991-12-24 | — | — | US | disclosed |
| EP-0397350-A1 | Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof | PFIZER INC. (US) | 1990-11-14 | — | — | EP | disclosed |
| US-4954629-A | Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof | PFIZER INC. (US) | 1990-09-04 | — | — | US | disclosed |
| US-4900844-A | Intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains | PFIZER INC. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4868301-A | Processes and intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains | PFIZER INC. (US) | 1989-09-19 | — | — | US | disclosed |
| EP-0322153-A2 | Heterocyclic oxophtalazinyl acetic acids | PFIZER INC. (US) | 1989-06-28 | — | — | EP | disclosed |
| EP-0295051-A2 | Preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains | PFIZER INC. (US) | 1988-12-14 | — | — | EP | disclosed |