Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | AKR1B1 | P15121 | 14/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9327258 | 0.84 | MAPT (0.78) | MAPTAKR1B1KMT2APOLBALOX15 | |
| SCHEMBL9374155 | 0.82 | RECQL (0.76) | MAPTKMT2A | |
| SCHEMBL6890822 | 0.81 | MAPT (1.00) | MAPTAKR1B1KMT2APOLBALOX15 | |
| SCHEMBL8957310 | 0.80 | KMT2A (0.77) | MAPTAKR1B1KMT2APTGDR2TSHR | |
| SCHEMBL10007138 | 0.79 | MAPT (0.79) | MAPTAKR1B1KMT2APOLBALOX15 | |
| SCHEMBL23966567 | 0.78 | MAPT (0.68) | MAPTAKR1B1KMT2APOLBALOX15 | |
| SCHEMBL8957218 | 0.78 | MAPT (0.68) | MAPTAKR1B1KMT2APOLBALOX15 | |
| SCHEMBL23915524 | 0.77 | MAPT (0.67) | MAPTAKR1B1KMT2APOLBALOX15 | |
| SCHEMBL23914750 | 0.77 | MAPT (0.75) | MAPTAKR1B1KMT2APOLBALOX15 | |
| SCHEMBL23915521 | 0.76 | MAPT (0.69) | MAPTAKR1B1KMT2APOLBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159976-A | Polymorph of zopolrestat monohydrate | PFIZER INC. (US) | 2000-12-12 | — | — | US | disclosed |
| EP-0982306-A2 | Polymorph of zopolrestat monohydrate | Pfizer Products Inc. (US) | 2000-03-01 | — | — | EP | disclosed |
| EP-0295051-B1 | PREPARATION OF OXOPHTHALAZINYL ACETIC ACIDS HAVING BENZOTHIAZOLE OR OTHER HETEROCYCLIC SIDE CHAINS | PFIZER INC. (US) | 1993-06-09 | — | — | EP | disclosed |
| US-4900844-A | Intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains | PFIZER INC. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4868301-A | Processes and intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains | PFIZER INC. (US) | 1989-09-19 | — | — | US | disclosed |