Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6343700 | 0.83 | ALDH1A1 (0.65) | ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL3547262 | 0.83 | CA12 (0.61) | ALDH1A1MEN1KMT2AALOX5GABRA1 | |
| SCHEMBL9373198 | 0.82 | THRA (0.52) | CTNNB1WNT3A | |
| SCHEMBL3543244 | 0.81 | MAPT (0.55) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL20058880 | 0.81 | MAPK1 (0.60) | ALDH1A1MEN1KMT2AALOX5GABRA1 | |
| SCHEMBL29620831 | 0.80 | TSHR (0.63) | GSK3BALDH1A1MEN1KMT2ACTNNB1 | |
| SCHEMBL426444 | 0.80 | TSHR (0.63) | GSK3BALDH1A1MEN1KMT2ACTNNB1 | |
| SCHEMBL10955996 | 0.80 | PDE4B (0.55) | ALDH1A1MEN1KMT2ACTNNB1WNT3A | |
| SCHEMBL4344454 | 0.80 | HTT (0.48) | GSK3BALDH1A1ALOX5MAPT | |
| SCHEMBL9378829 | 0.78 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2AALOX5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0607217-A1 | PYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-27 | — | — | EP | disclosed |
| WO-1993007137-A1 | PYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1993-04-15 | — | — | WO | disclosed |