Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | RARA | P10276 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380846 | 0.90 | BACE1 (0.52) | BACE1MEN1KMT2ACYP26A1CYP3A4 | |
| SCHEMBL9376571 | 0.88 | CYP26A1 (0.52) | BACE1MEN1KMT2ACYP26A1CYP3A4 | |
| SCHEMBL9375391 | 0.88 | CYP26A1 (0.52) | MEN1KMT2ACYP26A1CYP3A4RARA | |
| SCHEMBL9380901 | 0.87 | MEN1 (0.53) | BACE1MEN1KMT2ACYP26A1CYP3A4 | |
| SCHEMBL9840186 | 0.87 | CYP26A1 (0.51) | BACE1MEN1KMT2ACYP26A1CYP3A4 | |
| SCHEMBL9379538 | 0.87 | MEN1 (0.53) | MEN1KMT2ACYP26A1CYP3A4RARA | |
| SCHEMBL9374793 | 0.87 | CYP26A1 (0.53) | BACE1MEN1KMT2ACYP26A1CYP3A4 | |
| SCHEMBL9374775 | 0.86 | NPC1 (0.52) | MEN1KMT2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL9375240 | 0.86 | KMT2A (0.52) | MEN1KMT2ACYP26A1CYP3A4RARA | |
| SCHEMBL9375945 | 0.85 | MEN1 (0.54) | MEN1KMT2ACYP26A1CYP3A4RARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344634-B1 | Bicyclic carboxamides, process for their preparation and medicaments containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1994-03-30 | — | — | EP | claimed |
| WO-1991001986-A1 | N-(DIALKYLOXOPHOSPHINYLALKYL)-LACTAMS, PROCESS FOR PREPARING THEM AND DRUGS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1991-02-21 | — | — | WO | disclosed |