Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.51 |
| ▸ | RARA | P10276 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.49 |
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | RARB | P10826 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | RARG | P13631 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9375391 | 0.88 | CYP26A1 (0.52) | MEN1KMT2APOLBPKMTDP1 | |
| SCHEMBL9376571 | 0.88 | CYP26A1 (0.52) | MEN1KMT2APOLBCYP26A1RARA | |
| SCHEMBL9380096 | 0.88 | LMNA (0.51) | MEN1KMT2ALMNACYP26A1RARA | |
| SCHEMBL9840186 | 0.87 | CYP26A1 (0.51) | MEN1KMT2ACYP26A1RARACYP3A4 | |
| SCHEMBL9375261 | 0.87 | BACE1 (0.55) | MEN1KMT2APOLBCYP26A1RARA | |
| SCHEMBL9379538 | 0.87 | MEN1 (0.53) | MEN1KMT2APOLBTDP1CYP26A1 | |
| SCHEMBL9374793 | 0.87 | CYP26A1 (0.53) | MEN1KMT2APOLBCYP26A1RARA | |
| SCHEMBL9380805 | 0.86 | PTGS1 (0.50) | MEN1KMT2ACYP26A1RARACYP3A4 | |
| SCHEMBL9375240 | 0.86 | KMT2A (0.52) | MEN1KMT2APOLBPKMTDP1 | |
| SCHEMBL9380425 | 0.85 | MAPT (0.50) | MEN1KMT2ALMNACYP26A1RARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344634-B1 | Bicyclic carboxamides, process for their preparation and medicaments containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1994-03-30 | — | — | EP | disclosed |
| US-5019587-A | Anticoagulants | BOEHRINGER MANNHEIM GMBH (DE) | 1991-05-28 | — | — | US | disclosed |
| CN-1038640-A | Two ring carboxamide, its preparation methods and contain the pharmaceutical composition of this material | BOEHRINGER MANNHEIM GMBH (DE) | 1990-01-10 | — | — | CN | disclosed |
| EP-0344634-A1 | Bicyclic carboxamides, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1989-12-06 | — | — | EP | disclosed |