Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.92 |
| ▸ | PARP1 | P09874 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.57 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9377531 | 0.96 | SIGMAR1 (1.00) | SIGMAR1PARP1HTR1AS1PR1S1PR3 | |
| Maleic Acid SCHEMBL8092718 | 0.87 | SIGMAR1 (0.83) | SIGMAR1PARP1HTR1AS1PR1S1PR3 | |
| Fumaric Acid SCHEMBL8092721 | 0.87 | SIGMAR1 (0.83) | SIGMAR1PARP1HTR1AS1PR1S1PR3 | |
| SCHEMBL10287534 | 0.84 | SIGMAR1 (0.71) | SIGMAR1HTR1ADRD2 | |
| SCHEMBL9473840 | 0.81 | SIGMAR1 (0.92) | SIGMAR1PARP1DRD2 | |
| SCHEMBL30484775 | 0.81 | SIGMAR1 (0.66) | SIGMAR1PARP1HTR1AS1PR1S1PR3 | |
| SCHEMBL11938943 | 0.80 | SIGMAR1 (0.65) | SIGMAR1HTR1ADRD2 | |
| SCHEMBL6626009 | 0.80 | SIGMAR1 (0.65) | SIGMAR1PARP1HTR1ADRD2 | |
| SCHEMBL5846298 | 0.80 | SIGMAR1 (0.68) | SIGMAR1PARP1HTR1ADRD2 | |
| SCHEMBL7289482 | 0.79 | SIGMAR1 (0.67) | SIGMAR1PARP1HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | claimed |
| EP-0507863-A4 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | — | 1993-07-07 | — | — | EP | claimed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | claimed |
| EP-0507863-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1992-10-14 | — | — | EP | claimed |
| WO-1991009594-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1991-07-11 | — | — | WO | claimed |