Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9377426 | 0.86 | ADAM17 (0.47) | ADAM17MMP2ADAM10MMP1MMP14 | |
| SCHEMBL9380340 | 0.82 | DRD2 (0.49) | ADAM17MMP2ADAM10MMP1MMP14 | |
| SCHEMBL29370739 | 0.81 | PARP1 (0.46) | KDM4EALDH1A1HPGDALOX15TSHR | |
| SCHEMBL13091171 | 0.81 | KDM4E (0.45) | ADAM17KDM4EALDH1A1HPGDALOX15 | |
| SCHEMBL21421527 | 0.81 | ADAM17 (0.48) | ADAM17MMP2ADAM10MMP1MMP14 | |
| SCHEMBL14466388 | 0.81 | ADAM17 (0.48) | ADAM17MMP2ADAM10MMP1MMP14 | |
| SCHEMBL9690429 | 0.81 | ADAM17 (0.44) | ADAM17MMP2ADAM10MMP1MMP14 | |
| SCHEMBL28726671 | 0.80 | DPP4 (0.38) | DPP4PARP1PARP2DRD2DRD3 | |
| SCHEMBL2559394 | 0.79 | KDM4E (0.43) | KDM4EALDH1A1HPGDALOX15TSHR | |
| SCHEMBL19852200 | 0.78 | ADAM17 (0.46) | ADAM17MMP2ADAM10MMP1MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625978-A1 | PIPERAZINE AND PIPERIDINE DERIVATIVES, AND THEIR USE AS ANTIPSYCHOTICS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-11-30 | — | — | EP | disclosed |
| WO-1993016073-A1 | PIPERAZINE AND PIPERIDINE DERIVATIVES, AND THEIR USE AS ANTIPSYCHOTICS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-08-19 | — | — | WO | disclosed |